Integrated analysis of multiple data sources reveals modular structure of biological networks
文献类型：期刊论文
| 作者 | Lu, HC; Shi, BC; Wu, GW; Zhang, Y; Zhu, XP; Zhang, ZH; Liu, CN; Zhao, Y; Wu, T; Wang, J |
| 刊名 | Biochemical and biophysical research communications
 |
| 出版日期 | 2006-06-23 |
| 卷号 | 345期号:1页码:302-309 |
| 关键词 | Integrated analysis of multiple data sources Hierarchical clustering algorithm Protein-protein interaction network Modular structure of biological networks |
| ISSN号 | 0006-291X |
| DOI | 10.1016/j.bbrc.2006.04.088 |
| 通讯作者 | Chen, rs() |
| 英文摘要 | It has been a challenging task to integrate high-throughput data into investigations of the systematic and dynamic organization of biological networks. here, we presented a simple hierarchical clustering algorithm that goes a long way to achieve this aim. our method effectively reveals the modular structure of the yeast protein-protein interaction network and distinguishes protein complexes from functional modules by integrating high-throughput protein-protein interaction data with the added subcellular localization and expression profile data. furthermore, we take advantage of the detected modules to provide a reliably functional context for the uncharacterized components within modules. on the other hand, the integration of various protein-protein association information makes our method robust to false-positives, especially for derived protein complexes. more importantly, this simple method can be extended naturally to other types of data fusion and provides a framework for the study of more comprehensive properties of the biological network and other forms of complex networks. (c) 2006 elsevier inc. all rights reserved. |
| WOS关键词 | PROTEIN-PROTEIN INTERACTIONS ; SACCHAROMYCES-CEREVISIAE ; BUDDING YEAST ; SCALE DATA ; INTERACTOME ; COMPLEXES ; ORGANIZATION |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000237877700042 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2379103 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chen, RS |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, Bioinformat Lab, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Inst Comp Technol, Key Lab Intelligent Informat Proc, Bioinformat Res Grp, Beijing 100080, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, HC,Shi, BC,Wu, GW,et al. Integrated analysis of multiple data sources reveals modular structure of biological networks[J]. Biochemical and biophysical research communications,2006,345(1):302-309. |
| APA | Lu, HC.,Shi, BC.,Wu, GW.,Zhang, Y.,Zhu, XP.,...&Chen, RS.(2006).Integrated analysis of multiple data sources reveals modular structure of biological networks.Biochemical and biophysical research communications,345(1),302-309. |
| MLA | Lu, HC,et al."Integrated analysis of multiple data sources reveals modular structure of biological networks".Biochemical and biophysical research communications 345.1(2006):302-309. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。