An overall picture of sars coronavirus (sars-cov) genome-encoded major proteins: structures, functions and drug development
文献类型：期刊论文
| 作者 | Chen, Shuai; Luo, Haibin; Chen, Lili; Chen, Jing; Shen, Jianhua; Zhu, Weiliang; Chen, Kaixian; Shen, Xu; Jiang, Hualiang |
| 刊名 | Current pharmaceutical design
 |
| 出版日期 | 2006 |
| 卷号 | 12期号:35页码:4539-4553 |
| ISSN号 | 1381-6128 |
| 关键词 | Atypical pneumonia Sars coronavirus Sars-cov genome-encoded major proteins Structural and functional characterization Inhibitor design and screening Structure-based drug development |
| 通讯作者 | Shen, xu(xshen@mail.shcnc.ac.cn) |
| 英文摘要 | A severe atypical pneumonia designated as severe acute respiratory syndrome (sars) by the world health organization broke out in china and menaced to more than other 30 countries between the end of the year 2002 and june of the year 2003. a novel coronavirus called severe acute respiratory syndrome coronavirus (sars-cov) has been recently identified as the etiological agent responsible for the infectious sars disease. based on extensively scientific cooperation and almost two-year's studies, remarkable achievements have been made in the understanding of the phylogenetic property and the genome organization of sars-cov, as well as the detailed characters of the major proteins involved in sars-cov life cycle. in this review, we would like to summarize the substantial scientific progress that has been made towards the structural and functional aspects of sars-cov associated key proteins. the progress focused oil the corresponding key proteins' structure-based drug and vaccine developments has been also highlighted. the concerted and cooperative response for the treatment of the sars disease has been proved to be a triumph of global public health and provides a new paradigm for the detection and control of future emerging infectious disease threats. |
| WOS关键词 | ACUTE-RESPIRATORY-SYNDROME ; MOUSE HEPATITIS-VIRUS ; TRANSMISSIBLE GASTROENTERITIS CORONAVIRUS ; ANGIOTENSIN-CONVERTING ENZYME-2 ; NUCLEAR RIBONUCLEOPROTEIN A1 ; HELICASE-PRIMASE INHIBITORS ; DEPENDENT RNA-POLYMERASE ; NUCLEOCAPSID PROTEIN ; MEMBRANE-PROTEIN ; SPIKE PROTEIN |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| WOS记录号 | WOS:000242919900002 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2379881 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Shen, Xu |
| 作者单位 | 1.Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci,Drug Discovery & Design Ct, Shanghai Inst Mat Med,State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Shuai,Luo, Haibin,Chen, Lili,et al. An overall picture of sars coronavirus (sars-cov) genome-encoded major proteins: structures, functions and drug development[J]. Current pharmaceutical design,2006,12(35):4539-4553. |
| APA | Chen, Shuai.,Luo, Haibin.,Chen, Lili.,Chen, Jing.,Shen, Jianhua.,...&Jiang, Hualiang.(2006).An overall picture of sars coronavirus (sars-cov) genome-encoded major proteins: structures, functions and drug development.Current pharmaceutical design,12(35),4539-4553. |
| MLA | Chen, Shuai,et al."An overall picture of sars coronavirus (sars-cov) genome-encoded major proteins: structures, functions and drug development".Current pharmaceutical design 12.35(2006):4539-4553. |
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来源：中国科学院大学
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