Preparation and application of isoquinolinecarboxylic acid derivative as chiral stationary phase for ligand exchange chromatography
文献类型：期刊论文
| 作者 | Meng, QH; Wang, SQ; Guo, Y; Ma, YS; Long, YD; Huang, TB |
| 刊名 | Chinese journal of analytical chemistry
 |
| 出版日期 | 2006-03-01 |
| 卷号 | 34期号:3页码:311-315 |
| 关键词 | Isoquinoline derivative Ligand exchange chromatography Chiral stationary phase D L-amino acid |
| ISSN号 | 0253-3820 |
| 通讯作者 | Long, yd() |
| 英文摘要 | A novel chiral stationary phase (c-16-(s)-thiqca) for ligand exchange high performance liquid chromatography was prepared by synthesizing 2-(2-hydroxyl) hexadecyl-(s)-1 2,3,4-tetrahydro-3-isoquinolinecarboxylic acid as chiral selector and coating it on octadecyl. bonded silica (ods) bonded stationary phase. the enantiomeric resolutions of 16 d,l-amino acids were achieved on c-16-(s) -thiqca by using cupne acetate aqueous solution as mobile phase, column temperature 25 degrees c and detection at ultraviolet 254 nm. the enantioselectivities alpha of the d,l-amino acids separated were found to be in the range of 1.09 to 1.67 with the resolution r. ranging from 1.0 to 4.8. the elution order of d-isomer before l-isomer was observed for all d, l-amino acids used. the effects of chromatographic conditions including flow rate, column temperature, ph, the concentration of cu2+ and nh4+ on the resolutions of d,l-amino acid enantiomers were studied and discussed. |
| WOS关键词 | ALPHA-AMINO-ACIDS ; RESOLUTION ; SEPARATION |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Analytical |
| 语种 | 英语 |
| WOS记录号 | WOS:000236528300007 |
| 出版者 | SCIENCE PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2379962 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Long, YD |
| 作者单位 | 1.Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Meng, QH,Wang, SQ,Guo, Y,et al. Preparation and application of isoquinolinecarboxylic acid derivative as chiral stationary phase for ligand exchange chromatography[J]. Chinese journal of analytical chemistry,2006,34(3):311-315. |
| APA | Meng, QH,Wang, SQ,Guo, Y,Ma, YS,Long, YD,&Huang, TB.(2006).Preparation and application of isoquinolinecarboxylic acid derivative as chiral stationary phase for ligand exchange chromatography.Chinese journal of analytical chemistry,34(3),311-315. |
| MLA | Meng, QH,et al."Preparation and application of isoquinolinecarboxylic acid derivative as chiral stationary phase for ligand exchange chromatography".Chinese journal of analytical chemistry 34.3(2006):311-315. |
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来源：中国科学院大学
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