The high prevalence of the i27 mutant hbcag18-27 epitope in chinese hbv-infected patients and its cross-reactivity with the v27 prototype epitope
文献类型：期刊论文
| 作者 | Liu, Heng-Gui; Chen, Wei-wei; Fan, Zhen-Ping; Yang, Hui-ying; Shi, Ming; Zhang, Zheng; Luan, Shen-Shun; Zhang, Hui; Lu, Peng; Tien, Po |
| 刊名 | Clinical immunology
 |
| 出版日期 | 2007-12-01 |
| 卷号 | 125期号:3页码:337-345 |
| 关键词 | Immunology Clinic immunology and viral immunology Hepatitis b virus Epitope Mutation Cytotoxic t lymphocyte |
| ISSN号 | 1521-6616 |
| DOI | 10.1016/j.clim.2007.06.010 |
| 通讯作者 | Tien, po(tienpo@sun.im.ac.cn) |
| 英文摘要 | Hbcag18-27 (flpsdffpsv, v27 epitope) is a dominant hla-a2- restricted epitope in hepatitis b virus (hbv)-infected patients. so far, the occurrence of the epitope has not been assessed in china, where the prevalence of chronic hbv infection is high. in this report, we sequenced the hbv core gene in 105 chinese patients with chronic hbv infection. approximately 93.3% (98/105) of the core genes that were sequenced contained mutations with amino acid substitution at position 27 of the core protein: a mutation from a valine to an isoleucine (v27i). the mutant peptide (flpsdffpsi, 127) was found to bind to the hla-a2 molecule with high affinity and elicit specific cytotoxic t lymphocyte (ctl) responses in acutely infected hepatitis b patients. in ctl assays using 127-specific pentamer staining, the v27 epitope showed a cross-reactive t cell response specific for the 127 epitope, but not vice versa. these findings provide important insights for the design of h bcag18-27- based vaccines in the future. (c) 2007 elsevier inc. all rights reserved. |
| WOS关键词 | HEPATITIS-B-VIRUS ; T-CELL RESPONSES ; MAJOR HISTOCOMPATIBILITY COMPLEX ; CLASS-I ; PHYLOGENETIC RELATEDNESS ; LYMPHOCYTE RESPONSE ; ANTIGEN ; IDENTIFICATION ; GENOTYPES ; RECEPTOR |
| WOS研究方向 | Immunology |
| WOS类目 | Immunology |
| 语种 | 英语 |
| WOS记录号 | WOS:000251486100015 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2380245 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Tien, Po |
| 作者单位 | 1.Beijing Inst Infect Dis, Res Ctr Biol Theraphy, Beijing Hosp 302, Beijing 100039, Peoples R China 2.Chinese Acad Sci, Inst Microbiol, Ctr Mol Virol, Beijing 100080, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Heng-Gui,Chen, Wei-wei,Fan, Zhen-Ping,et al. The high prevalence of the i27 mutant hbcag18-27 epitope in chinese hbv-infected patients and its cross-reactivity with the v27 prototype epitope[J]. Clinical immunology,2007,125(3):337-345. |
| APA | Liu, Heng-Gui.,Chen, Wei-wei.,Fan, Zhen-Ping.,Yang, Hui-ying.,Shi, Ming.,...&Wang, Fu-Sheng.(2007).The high prevalence of the i27 mutant hbcag18-27 epitope in chinese hbv-infected patients and its cross-reactivity with the v27 prototype epitope.Clinical immunology,125(3),337-345. |
| MLA | Liu, Heng-Gui,et al."The high prevalence of the i27 mutant hbcag18-27 epitope in chinese hbv-infected patients and its cross-reactivity with the v27 prototype epitope".Clinical immunology 125.3(2007):337-345. |
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来源：中国科学院大学
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