Collagen membranes loaded with collagen-binding human pdgf-bb accelerate wound healing in a rabbit dermal ischemic ulcer model
文献类型：期刊论文
| 作者 | Sun, Wenjie1,3; Lin, Hang1; Xie, Hua2; Chen, Bing1; Zhao, Wenxue1; Han, Qianqian1; Zhao, Yannan1; Xiao, Zhifeng1; Dai, Jianwu1 |
| 刊名 | Growth factors
 |
| 出版日期 | 2007-10-01 |
| 卷号 | 25期号:5页码:309-318 |
| 关键词 | Pdgf-bb Collagen-binding domain Ulcer healing Angiogenesis |
| ISSN号 | 0897-7194 |
| DOI | 10.1080/08977190701803885 |
| 通讯作者 | Dai, jianwu(jwdai@genetics.ac.cn) |
| 英文摘要 | Studies have shown that exogenous platelet-derived growth factor-bb (pdgf-bb) could accelerate the ulcer healing, but the lack of efficient growth factor delivery system limits its clinical application. our previous work has demonstrated that the native human pdgf-bb was added a collagen-binding domain (cbd), tkktlrt, to develop a collagen-based pdgf targeting delivery system. here, we showed that this cbd-fused pdgf-bb (cbd-pdgf) could bind to collagen membrane efficiently. we used the rabbit dermal ischemic ulcer model to study the effects of cbd-pdgf loaded on collagen membranes. results revealed that this system maintained a higher concentration and stronger bioactivity of pdgf-bb on the collagen membranes and promoted the re-epithelialization of dermal ulcer wounds, the collagen deposition, and the formation of capillary lumens within the newly formed tissue area. it demonstrated that collagen membranes loaded with collagen-targeting human pdgf-bb could effectively promote ulcer healing. |
| WOS关键词 | PHASE-I TRIAL ; GROWTH-FACTOR ; MOLECULAR-MECHANISMS ; TISSUE-REPAIR ; MATRIX ; SAFETY ; H5.020CMV.PDGF-B ; REGENERATION ; TRANSDUCTION ; FIBROBLASTS |
| WOS研究方向 | Cell Biology ; Endocrinology & Metabolism |
| WOS类目 | Cell Biology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000253316800002 |
| 出版者 | TAYLOR & FRANCIS LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2380531 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Dai, Jianwu |
| 作者单位 | 1.Chinese Acad Sci, Inst Genet & Dev Biol, Key Lab Mol Dev Biol, Beijing 100080, Peoples R China 2.Kunming Med Coll, Yunnan 650031, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Wenjie,Lin, Hang,Xie, Hua,et al. Collagen membranes loaded with collagen-binding human pdgf-bb accelerate wound healing in a rabbit dermal ischemic ulcer model[J]. Growth factors,2007,25(5):309-318. |
| APA | Sun, Wenjie.,Lin, Hang.,Xie, Hua.,Chen, Bing.,Zhao, Wenxue.,...&Dai, Jianwu.(2007).Collagen membranes loaded with collagen-binding human pdgf-bb accelerate wound healing in a rabbit dermal ischemic ulcer model.Growth factors,25(5),309-318. |
| MLA | Sun, Wenjie,et al."Collagen membranes loaded with collagen-binding human pdgf-bb accelerate wound healing in a rabbit dermal ischemic ulcer model".Growth factors 25.5(2007):309-318. |
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来源：中国科学院大学
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