Combined action of ace gene i/d and gnb3 gene c825t polymorphisms on essential hypertension in northern han chinese
文献类型：期刊论文
| 作者 | Huang Wen-Tao; Yu Hong-Jiang; Lu Xiang-Feng; Zhao Wei-Yan; Wang Yue-Lan; Gu Dong-Feng; Chen Run-Sheng |
| 刊名 | Progress in biochemistry and biophysics
 |
| 出版日期 | 2007 |
| 卷号 | 34期号:5页码:471-478 |
| 关键词 | Angiotensin-converting enzyme G-protein beta3 subunit Interaction Combination effect Hypertension |
| ISSN号 | 1000-3282 |
| 通讯作者 | Chen run-sheng(crs@sun5.ibp.ac.cn) |
| 英文摘要 | Essential hypertension (eh), a complex polygenic disease, is considered to the result of the genetic interaction of multiple gene alterations in concert with environmental factors. evidences showed that angiotensin-converting enzyme (ace) gene and g protein beta3 subunit (gnb3) gene are both important susceptibility genes for eh, and that there exists putative biological connection between the two genes in developing hypertension. to investigate whether hypertension was affected by gene-gene interaction between the two genes in the northern chinese han population, a case-control association study including 502 hypertensive cases and 490 healthy controls was conducted, selecting the ace gene i/d polymorphism and the gnb3 gene c825t polymorphism. linkage disequilibrium analysis revealed a significant nonrandom distribution only in male hypertensives, indicating that interaction between ace gene and gnb3 gene may predispose males to the occurrence of hypertension. multivariate stepwise logistic regression in single locus analysis, with adjustment for common risk factors for hypertension, demonstrated that the or for dd/id versus 11 for hypertension among men was significant (or 1.57; 95% ci, 1.09 similar to 2.27; p = 0.0 16) in dominant genetic model. in combination analysis stratified with respect to gender, slightly significant ors were found after adjustment in males: or for tt vs cc, 0.11; 95% ci, 0.01 similar to 0.99; p=0.049 within ace dd genotype; or for dd/id vs ii, 1.52; 95% ci, 1.01 similar to 2.29; p = 0.047 within gnb3 cc+ct genotype. the results suggest that ace, or a nearby gene, is a male-specific susceptible gene for hypertension, and that there may exist epistatic gene-gene interaction between ace d allele and gn133 825c allele. |
| WOS关键词 | INSERTION-DELETION POLYMORPHISM ; WHOLE-GENOME ASSOCIATION ; SUBUNIT 825T ALLELE ; BLOOD-PRESSURE ; ANGIOTENSIN ; SYSTEM ; PREVALENCE ; LINKAGE ; MEN |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000247366100005 |
| 出版者 | CHINESE ACAD SCIENCES, INST BIOPHYSICS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2380831 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chen Run-Sheng |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Chinese Natl Human Genome Ctr, Beijing 100176, Peoples R China 4.Chinese Acad Med Sci, Fuwai Hosp, Beijing 100037, Peoples R China 5.Chinese Acad Med Sci, Div Populat Genet & Prevent, Cardiovasc Inst, Beijing 100037, Peoples R China 6.Peking Union Med Coll, Beijing 100037, Peoples R China 7.Beijing Inst Biotechnol, Beijing 100071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang Wen-Tao,Yu Hong-Jiang,Lu Xiang-Feng,et al. Combined action of ace gene i/d and gnb3 gene c825t polymorphisms on essential hypertension in northern han chinese[J]. Progress in biochemistry and biophysics,2007,34(5):471-478. |
| APA | Huang Wen-Tao.,Yu Hong-Jiang.,Lu Xiang-Feng.,Zhao Wei-Yan.,Wang Yue-Lan.,...&Chen Run-Sheng.(2007).Combined action of ace gene i/d and gnb3 gene c825t polymorphisms on essential hypertension in northern han chinese.Progress in biochemistry and biophysics,34(5),471-478. |
| MLA | Huang Wen-Tao,et al."Combined action of ace gene i/d and gnb3 gene c825t polymorphisms on essential hypertension in northern han chinese".Progress in biochemistry and biophysics 34.5(2007):471-478. |
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来源：中国科学院大学
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