Anti-nociceptive effects induced by intrathecal injection of bmk as, a polypeptide from the venom of chinese-scorpion buthus martensi karsch, in rat formalin test
文献类型：期刊论文
| 作者 | Liu, Tong2; Pang, Xue-Yan1; Jiang, Feng1; Bai, Zhan-Tao2; Ji, Yong-Hua1 |
| 刊名 | Journal of ethnopharmacology
 |
| 出版日期 | 2008-05-08 |
| 卷号 | 117期号:2页码:332-338 |
| 关键词 | Bmk as Sodium channels Formalin test Anti-nociception C-fos expression |
| ISSN号 | 0378-8741 |
| DOI | 10.1016/j.jep.2008.02.003 |
| 通讯作者 | Ji, yong-hua(yhji@server.shcnc.ac.cn) |
| 英文摘要 | Aim of the study: asian scorpion buthus martensi karsch (bmk) is widely used to treat neurological symptoms, especially chronic pain, in traditional chinese medicine for thousands of years. bmk as, a polypeptide from bmk venom, could produce peripheral potent anti-nociceptive effects in rats. in the present study, spinal anti-nociceptive effects of bmk as were investigated in rat formalin test. materials and methods: spinal anti-nociceptive activity of bmk as was studied using formalin test in rats. bmk as in doses of 0.02, 0.1 and 0.5 mu g was administered intrathecally before formalin injection 10 min. the suppression by intrathecal injection of bmk as on formalin-induced spontaneous nociceptive behaviors and spinal c-fos expression were investigated. results: intrathecal injection of bmk as markedly reduced formalin-evoked biphasic spontaneous nociceptive behaviors in a dose-dependent manner. formalin-induced c-fos expression could be dose-dependently inhibited by bmk as in superficial (i-ii), the nucleus proprius (iii and iv) and deep (v-vi) dorsal horn laminae, but not in the ventral gray laminae (vii-x) of lumbar spinal cord. the suppression by bmk as on c-fos expression in superficial laminaes was much stronger than that in deep laminaes. conclusion: the present study demonstrates that bmk as is capable of producing remarkable anti-nociceptive effects not only in periphery but also in spinal cord. (c) 2008 elsevier ireland ltd. all rights reserved. |
| WOS关键词 | GATED SODIUM-CHANNELS ; C-FOS EXPRESSION ; SKELETAL-MUSCLE ; SPINAL-CORD ; NOCICEPTIVE RESPONSE ; ACTIVE POLYPEPTIDE ; RYANODINE RECEPTOR ; POSSIBLE MECHANISM ; NA+ CHANNELS ; PAIN |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| WOS类目 | Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000256207700018 |
| 出版者 | ELSEVIER IRELAND LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2385194 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Ji, Yong-Hua |
| 作者单位 | 1.Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Physiol, Grad Sch, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Tong,Pang, Xue-Yan,Jiang, Feng,et al. Anti-nociceptive effects induced by intrathecal injection of bmk as, a polypeptide from the venom of chinese-scorpion buthus martensi karsch, in rat formalin test[J]. Journal of ethnopharmacology,2008,117(2):332-338. |
| APA | Liu, Tong,Pang, Xue-Yan,Jiang, Feng,Bai, Zhan-Tao,&Ji, Yong-Hua.(2008).Anti-nociceptive effects induced by intrathecal injection of bmk as, a polypeptide from the venom of chinese-scorpion buthus martensi karsch, in rat formalin test.Journal of ethnopharmacology,117(2),332-338. |
| MLA | Liu, Tong,et al."Anti-nociceptive effects induced by intrathecal injection of bmk as, a polypeptide from the venom of chinese-scorpion buthus martensi karsch, in rat formalin test".Journal of ethnopharmacology 117.2(2008):332-338. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。