Biodegradable and thermoreversible hydrogels of poly(ethylene glycol)-poly(epsilon-caprolactone-co-glycolide)-poly(ethylene glycol) aqueous solutions
文献类型：期刊论文
| 作者 | Jiang, Zhiqiang1,2; Hao, Jianyuan1,2; You, YuJing; Liu, Yan3; Wang, Zhenhong3; Deng, Xianmo1,2 |
| 刊名 | Journal of biomedical materials research part a
 |
| 出版日期 | 2008-10-01 |
| 卷号 | 87a期号:1页码:45-51 |
| 关键词 | Biomaterials Hydrogels Sol-gel Block copolymer Biodegradable |
| ISSN号 | 1549-3296 |
| DOI | 10.1002/jbm.a.31699 |
| 通讯作者 | Hao, jianyuan(j.hao@cioc.ac.cn) |
| 英文摘要 | The aqueous solutions of triblock copolymers of poly(ethylene glycol)-poly(epsilon-caprolactoiie-co-glycolide)-poly(eihylene glycol) [peg-p(cl-ga)-peg] undergoing sol-gel transition as the temperature increases from 20 to 60 degrees c were successfully prepared. the thermogelling block copolymers were synthesized by subtle control of the hydrophilic/hydrophobic balance and the chain microstructures. the amphiphilic block copolymer formed micelles in aqueous solution, and the micelle aggregated as the temperature increased. the sol-gel transition of the copolymer aqueous solutions was studied focusing on the structure-property relationship. ga was incorporated into the polymer chain to prevent crystallization of pcl component and increase the polymer degradation. it is expected to be a promising long-term delivery system for ph-sensitive drugs, proteins, and genes. (c) 2007 wiley periodicals, inc. |
| WOS关键词 | STRUCTURE-PROPERTY RELATIONSHIPS ; RING-OPENING POLYMERIZATION ; MIXED TRIBLOCK COPOLYMERS ; PLGA-PEG-PLGA ; BLOCK-COPOLYMERS ; CAPILLARY-ELECTROPHORESIS ; EPSILON-CAPROLACTONE ; DNA SEPARATION ; DELIVERY ; ASSOCIATION |
| WOS研究方向 | Engineering ; Materials Science |
| WOS类目 | Engineering, Biomedical ; Materials Science, Biomaterials |
| 语种 | 英语 |
| WOS记录号 | WOS:000259129500007 |
| 出版者 | WILEY-LISS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2385350 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Hao, Jianyuan |
| 作者单位 | 1.Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China 2.Chinese Acad Sci, Grad Univ, Dept Chem, Beijing 100039, Peoples R China 3.Sichuan Univ, Polymer Res Inst, State Key Lab Polymer Mat & Engn, Chengdu 610065, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Zhiqiang,Hao, Jianyuan,You, YuJing,et al. Biodegradable and thermoreversible hydrogels of poly(ethylene glycol)-poly(epsilon-caprolactone-co-glycolide)-poly(ethylene glycol) aqueous solutions[J]. Journal of biomedical materials research part a,2008,87a(1):45-51. |
| APA | Jiang, Zhiqiang,Hao, Jianyuan,You, YuJing,Liu, Yan,Wang, Zhenhong,&Deng, Xianmo.(2008).Biodegradable and thermoreversible hydrogels of poly(ethylene glycol)-poly(epsilon-caprolactone-co-glycolide)-poly(ethylene glycol) aqueous solutions.Journal of biomedical materials research part a,87a(1),45-51. |
| MLA | Jiang, Zhiqiang,et al."Biodegradable and thermoreversible hydrogels of poly(ethylene glycol)-poly(epsilon-caprolactone-co-glycolide)-poly(ethylene glycol) aqueous solutions".Journal of biomedical materials research part a 87a.1(2008):45-51. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。