Preparation of low molecular weight alginate by hydrogen peroxide depolymerization for tissue engineering
文献类型：期刊论文
| 作者 | Li, Xiaoxia1,2; Xu, Aihua3; Xie, Hongguo1,2; Yu, Weiting1,2; Xie, Weiyang1; Ma, Xiaojun1 |
| 刊名 | carbohydrate polymers
 |
| 出版日期 | 2010-02-11 |
| 卷号 | 79期号:3页码:660-664 |
| 关键词 | Alginate Oxidation Hydrogen peroxide Scaffold |
| 产权排序 | 1;1 |
| 通讯作者 | 马小军 |
| 英文摘要 | oxidation reactions of alginate solution with h(2)o(2) were performed under different conditions to prepare low molecular weight alginate, and its potential application for tissue engineering was investigated. h(2)o(2) oxidation is an effective method for alginate depolymerization with the rate depending on reaction time, temperature, solution ph and h(2)o(2) concentration. the structure analyses by ft-ir, elemental analysis and (13)c nmr indicated that, the rupture of glucoside bonds in alginate chains into low molecular weight polymers is the basic process during h(2)o(2) depolymerization. oxidation of alginate under weak oxidation conditions (h(2)o(2) 0.6% (w/v), 50 degrees c, 1 h) did not significantly interfere in the formation of ionic junctions with calcium ions. the cross-linked alginate scaffold prepared from the obtained alginate under these conditions showed faster degradation rate than that from the unmodified alginate, due to the lower molecular weight of oxidized alginate and the formed aldehyde groups susceptible to hydrolysis. (c) 2009 elsevier ltd. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, applied ; chemistry, organic ; polymer science |
| 研究领域[WOS] | chemistry ; polymer science |
| 关键词[WOS] | controlled scaffold degradation ; nmr-spectroscopy ; bone-formation ; in-vivo ; chitosan ; oxidation ; delivery ; acid ; hydrolysis ; starch |
| 收录类别 | SCI |
| 原文出处 | false |
| 语种 | 英语 |
| WOS记录号 | WOS:000273864500025 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/103111]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Wuhan 430074, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xiaoxia,Xu, Aihua,Xie, Hongguo,et al. Preparation of low molecular weight alginate by hydrogen peroxide depolymerization for tissue engineering[J]. carbohydrate polymers,2010,79(3):660-664. |
| APA | Li, Xiaoxia,Xu, Aihua,Xie, Hongguo,Yu, Weiting,Xie, Weiyang,&Ma, Xiaojun.(2010).Preparation of low molecular weight alginate by hydrogen peroxide depolymerization for tissue engineering.carbohydrate polymers,79(3),660-664. |
| MLA | Li, Xiaoxia,et al."Preparation of low molecular weight alginate by hydrogen peroxide depolymerization for tissue engineering".carbohydrate polymers 79.3(2010):660-664. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。