机构

• 化学研究所 [30]
• 金属研究所 [19]
• 上海药物研究所 [16]
• 过程工程研究所 [11]
• 上海硅酸盐研究所 [9]
• 长春应用化学研究所 [8]
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• OAI收割 [134]
• iSwitch采集 [5]

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• 期刊论文 [138]
• 学位论文 [1]

发表日期

• 2023 [3]
• 2022 [4]
• 2021 [4]
• 2020 [9]
• 2019 [14]
• 2018 [9]
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学科主题

• Biochemist... [4]
• Chemistry [3]
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浏览/检索结果: 共139条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Discovery of a 1,6-naphthyridin-4-one-based AXL inhibitor with improved pharmacokinetics and enhanced in vivo antitumor efficacy 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 17 作者:  Lan, Yaohan;  Peng, Xia;  Ji, Yinchun;  Su, Yi;  Duan, Wenhu   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/02/27 AXL inhibitor  In vivo antitumor efficacy  6-Naphthyridin-4-one derivatives  Scaffold hopping  Structure-based drug design   Structural insights into the interaction of three Y- shaped ligands with PI3Kα 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 卷号: 120, 期号: 34, 页码: 9 作者:  Zhou, Qingtong   |  收藏  |  浏览/下载：8/0  |  提交时间：2023/12/08 phosphoinositide 3-kinase  drug target  ligand  binding pocket  chemical scaffold   Optimization of potent, selective and orally bioavailable biphenyl scaffold as FABP4 inhibitors for anti-inflammation 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 253, 页码: 16 作者:  He, Yulong;  Li, Shunyi;  Zhu, Yueyue;  Wang, Yujie;  Chen, Yuqi   |  收藏  |  浏览/下载：62/0  |  提交时间：2023/10/17 Structure-activity relationship  FABP4 inhibitor  Biphenyl scaffold  Selectivity  Oral bioavailability  Anti-inflammation   Discovery of pyrido[4,3-d]pyrimidinone derivatives as novel Wee1 inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 87, 页码: 12 作者:  Ye, Qingqing;  Ma, Jingkun;  Wang, Peipei;  Wang, Chang;  Sun, Mei   |  收藏  |  浏览/下载：9/0  |  提交时间：2023/10/17 Wee1 inhibitor  Scaffold hopping   Design, synthesis and biological evaluation of novel dihydrobenzodioxine derivatives as HBV capsid protein inhibitors 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2022, 卷号: 128, 页码: 12 作者:  Liu, Linyue;  Li, Chuanju;  Xie, Yong;  Zhang, Lei;  Chen, Yunfu   |  收藏  |  浏览/下载：10/0  |  提交时间：2023/10/17 HBV  Capsid protein inhibitors  Pharmacophore hybrid  Scaffold hopping  HepAD38 cells   Dynamic process enhancement on chitosan/gelatin/nano-hydroxyapatite-bone derived multilayer scaffold for osteochondral tissue repair 期刊论文  OAI收割 BIOMATERIALS ADVANCES, 2022, 卷号: 133, 页码: 17 作者:  Hu, Xueyan;  Zheng, Shuangshuang;  Zhang, Rui;  Wang, Yiwei;  Jiao, Zeren   |  收藏  |  浏览/下载：17/0  |  提交时间：2023/02/24 Chitosan  gelatin  nano-hydroxyapatite multilayer  scaffold  Bone-derived scaffold  Dynamic environment  Osteochondral tissue regeneration   Fully Reduced HMGB1-Containing Peptide-Based Polyurethane Scaffold with Minimal Functional Unit of Skin (MFUS) Enhances Large and Deep Wounded Skin Healing 期刊论文  OAI收割 MACROMOLECULAR BIOSCIENCE, 2022, 卷号: 22, 期号: 2, 页码: 1-13 作者:  Chang P(常鹏);  Li SJ(李世杰);  Sun, Qian;  Guo K(郭凯);  Wang HR(王赫然)   |  收藏  |  浏览/下载：37/0  |  提交时间：2021/11/27 fully reduced HMGB1  lysine-di-isocyanate  minimal functional unit of skin  urethane polymer scaffold  wound healing   Large full-thickness wounded skin regeneration using 3D-printed elastic scaffold with minimal functional unit of skin 期刊论文  OAI收割 JOURNAL OF TISSUE ENGINEERING, 2022, 卷号: 13, 页码: 1-17 作者:  Chang P(常鹏);  Li SJ(李世杰);  Sun, Qian;  Guo K(郭凯);  Wang HR(王赫然)   |  收藏  |  浏览/下载：33/0  |  提交时间：2022/01/20 3D-printed PLCL scaffold  tissue engineering skin  skin wound healing  minimal functional unit of skin  biomaterial scaffolds   Manipulation of Multiple Cell-Cell Interactions by Tunable DNA Scaffold Networks 期刊论文  OAI收割 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021 作者:  Guo, Zhenzhen;  Zhang, Lili;  Yang, Qiuxia;  Peng, Ruizi;  Yuan, Xi   |  收藏  |  浏览/下载：40/0  |  提交时间：2022/01/25 Cell Encapsulation  Cell Manipulation  Cell-Cell Interactions  DNA Nanotechnology  DNA Scaffold Network   Design, synthesis and pharmacological evaluation of bicyclic and tetracyclic pyridopyrimidinone analogues as new KRAS(G12C) inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 213, 页码: 17 作者:  Xiao, Xuanzheng;  Lai, Mengzhen;  Song, Zilan;  Geng, Meiyu;  Ding, Jian   |  收藏  |  浏览/下载：26/0  |  提交时间：2021/05/24 KRAS  Covalent inhibitor  Pyridopyrimidinone  Antiproliferative effect  Scaffold hopping