Delayed liver injury and impaired hepatocyte proliferation after carbon tetrachloride exposure in bpoz2-deficient mice
文献类型：期刊论文
| 作者 | Zhang, Feng1,2,3,6; Shu, Runzhe1,2,3,6; Wu, Xiaolin3; Zhao, Xiaoping3; Feng, Dechun1,2,6; Wang, Long4,5; Lu, Shunyuan4,5; Liu, Qiaoling5; Xiang, Yougui5; Fei, Jian5 |
| 刊名 | Toxicology letters
 |
| 出版日期 | 2009-08-10 |
| 卷号 | 188期号:3页码:201-207 |
| 关键词 | Carbon tetrachloride Bpoz2 Liver injury Hepatocyte proliferation Cyclin d1 Erk |
| ISSN号 | 0378-4274 |
| DOI | 10.1016/j.toxlet.2009.04.009 |
| 通讯作者 | Wang, zhugang(zhugangw@shsmu.edu.cn) |
| 英文摘要 | Bpoz2 is a tumor suppressive mediator in pten signaling pathway and plays an important role in cell proliferation. in this study, we investigated the physiology functions of bpoz2 in ccl(4)-induced liver injury and hepatocyte proliferation afterwards. after acute ccl(4) administration, bpoz2 null mice exhibited delayed liver injury and impaired hepatocyte proliferation, which was accompanied by altered kinetics of cyp2e1 protein expression, compromised cyclin d1 expression and shortened duration of erk activation. these results for the first time define that bpoz2 is an important regulator involved in the injury and repair process induced by acute ccl(4) administration in mouse liver. (c) 2009 elsevier ireland ltd. all rights reserved. |
| WOS关键词 | CYCLIN D1 ; SIGNALING PATHWAY ; ANKYRIN REPEAT ; INTERLEUKIN-6-DEFICIENT MICE ; FACTOR RECEPTOR ; REGENERATION ; GROWTH ; PROTEIN ; GENE ; EXPRESSION |
| WOS研究方向 | Toxicology |
| WOS类目 | Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000267902200005 |
| 出版者 | ELSEVIER IRELAND LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2394084 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, Zhugang |
| 作者单位 | 1.Chinese Acad Sci, Inst Hlth Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Shanghai 200031, Peoples R China 3.SJTUSM, Inst Shanghai Univ E, Model Organism Div, Dept Med Genet, Shanghai 200025, Peoples R China 4.SJTUSM, Rui Jin Hosp, State Key Lab Med Genom, Shanghai 200025, Peoples R China 5.Shanghai Res Ctr Model Organisms, Shanghai 201210, Peoples R China 6.Chinese Acad Sci, Grad Sch, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Feng,Shu, Runzhe,Wu, Xiaolin,et al. Delayed liver injury and impaired hepatocyte proliferation after carbon tetrachloride exposure in bpoz2-deficient mice[J]. Toxicology letters,2009,188(3):201-207. |
| APA | Zhang, Feng.,Shu, Runzhe.,Wu, Xiaolin.,Zhao, Xiaoping.,Feng, Dechun.,...&Wang, Zhugang.(2009).Delayed liver injury and impaired hepatocyte proliferation after carbon tetrachloride exposure in bpoz2-deficient mice.Toxicology letters,188(3),201-207. |
| MLA | Zhang, Feng,et al."Delayed liver injury and impaired hepatocyte proliferation after carbon tetrachloride exposure in bpoz2-deficient mice".Toxicology letters 188.3(2009):201-207. |
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来源：中国科学院大学
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