Modification of chiral stationary phases with l-proline as a selector for ligand-exchange chromatography via introducing hydrophobic groups
文献类型：期刊论文
| 作者 | Shi Hong-yu1,2; Zhang Hai-zhu1,2; Long Yuan-de1; Huang Tian-bao1 |
| 刊名 | Chemical research in chinese universities
 |
| 出版日期 | 2009-11-25 |
| 卷号 | 25期号:6页码:822-826 |
| 关键词 | Ligand exchange chromatography Chiral stationary phase Enantioseparation Amino acid Hydroxyl acid |
| ISSN号 | 1005-9040 |
| 通讯作者 | Huang tian-bao(tbhuang@cioc.ac.cn) |
| 英文摘要 | Three chiral stationary phases(csp1, csp2 and csp3) for ligand-exchange chromatography were prepared by firstly using dimethylchlorosilane as an endcapping reagent for decreasing residual silanol groups on the surface of silica gel, and then modifying the surface of silica gel with allyl glycidyl ether and alkenes through the hydrosilation reaction, and lastly introducing l-proline as a chiral selector. the enantiomer resolutions of 14 amino acids and 2 hydroxyl acids were completed on the csps by using an aqueous solution of cu(ac)(2) as mobile phase at a flow rate of 1.0 ml/min and column temperature of 40 degrees c with detection at uv 254 run. in terms of enantioselectivity alpha, column efficiency and resolution r(s), the chromatographic behaviors of the analytes on the csps were discussed via comparing them to those on the csp4 prepared via the reference method. the results show that enantioselectivity alpha, column efficiency and resolution r(s) of the analytes on the csps could be improved by using the above modifying method. |
| WOS关键词 | LIQUID-CHROMATOGRAPHY ; AMINO-ACIDS ; RESOLUTION |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000272832000009 |
| 出版者 | HIGHER EDUCATION PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2397921 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Huang Tian-bao |
| 作者单位 | 1.Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi Hong-yu,Zhang Hai-zhu,Long Yuan-de,et al. Modification of chiral stationary phases with l-proline as a selector for ligand-exchange chromatography via introducing hydrophobic groups[J]. Chemical research in chinese universities,2009,25(6):822-826. |
| APA | Shi Hong-yu,Zhang Hai-zhu,Long Yuan-de,&Huang Tian-bao.(2009).Modification of chiral stationary phases with l-proline as a selector for ligand-exchange chromatography via introducing hydrophobic groups.Chemical research in chinese universities,25(6),822-826. |
| MLA | Shi Hong-yu,et al."Modification of chiral stationary phases with l-proline as a selector for ligand-exchange chromatography via introducing hydrophobic groups".Chemical research in chinese universities 25.6(2009):822-826. |
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来源：中国科学院大学
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