Synthesis of rupestonic acid benzyl ester derivatives and in vitro anti influenza virus and herpes simplex type i and ii viruses
文献类型：期刊论文
| 作者 | Yong Jianping1,2; Aisa, Haji Akber1; Nie Lifei1,2 |
| 刊名 | Chinese journal of organic chemistry
 |
| 出版日期 | 2009-10-01 |
| 卷号 | 29期号:10页码:1640-1644 |
| 关键词 | Synthesis Rupestonic acid ester derivative Influenza virus Herpes simplex virus Biological activity |
| ISSN号 | 0253-2786 |
| 通讯作者 | Yong jianping() |
| 英文摘要 | To improve rupestonic acid biological activities, ten rupestonic acid benzyl ester derivatives were synthesized in the presence of dcc/dmap with the rupestonic acid and substituted benzyl alcohol as starting materials. the synthesized compounds 2a similar to 2j were confirmed by the methods of ir, (1)h nmr, esi-ms and preliminarily assayed in vitro against influenza viruses a3, b and herpes simplex virus i (hsv-i), herpes simplex virus ii (hsv-ii). the results showed that most of the synthesized compounds had distinct inhibition against influenza viruses, 2e exhibited in vitro inhibitory activity against both influenza a3 and b viruses with ic(50) values of 5.5, 5.5 mu mol/l, respectively, and 2i showed higher activity against influenza a virus with an ic(50) value of 7.8 mu mol/l. therefore, compounds 2e, 2i can be as lead compounds for anti-flu agent. most of the compounds showed higher inhibition against hsv-i and hsv-ii viruses at 0.1 mu g/ml concentration. |
| WOS关键词 | AMIDE DERIVATIVES ; A(3) |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Organic |
| 语种 | 英语 |
| WOS记录号 | WOS:000271694600022 |
| 出版者 | SCIENCE PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2401257 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yong Jianping |
| 作者单位 | 1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Nat Prod Chem, Urumqi 830011, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yong Jianping,Aisa, Haji Akber,Nie Lifei. Synthesis of rupestonic acid benzyl ester derivatives and in vitro anti influenza virus and herpes simplex type i and ii viruses[J]. Chinese journal of organic chemistry,2009,29(10):1640-1644. |
| APA | Yong Jianping,Aisa, Haji Akber,&Nie Lifei.(2009).Synthesis of rupestonic acid benzyl ester derivatives and in vitro anti influenza virus and herpes simplex type i and ii viruses.Chinese journal of organic chemistry,29(10),1640-1644. |
| MLA | Yong Jianping,et al."Synthesis of rupestonic acid benzyl ester derivatives and in vitro anti influenza virus and herpes simplex type i and ii viruses".Chinese journal of organic chemistry 29.10(2009):1640-1644. |
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来源：中国科学院大学
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