Combined r-alpha-lipoic acid and acetyl-l-carnitine exerts efficient preventative effects in a cellular model of parkinson's disease
文献类型：期刊论文
| 作者 | Zhang, Hongyu2; Jia, Haiqun2,3; Liu, Jianghai2; Ao, Ni2; Yan, Bing2,3; Shen, Weili2; Wang, Xuemin4; Li, Xin2; Luo, Cheng2; Liu, Jiankang1,5 |
| 刊名 | Journal of cellular and molecular medicine
 |
| 出版日期 | 2010 |
| 卷号 | 14期号:1-2页码:215-225 |
| 关键词 | Lipoic acid Acetyl-l-carnitine Mitochondrial dysfunction Oxidative damage Parkinson's disease |
| ISSN号 | 1582-4934 |
| DOI | 10.1111/j.1582-4934.2008.00390.x |
| 通讯作者 | Liu, jiankang(j.liu@mail.xjtu.edu.cn) |
| 英文摘要 | Mitochondrial dysfunction and oxidative damage are highly involved in the pathogenesis of parkinson's disease (pd). some mitochondrial antioxidants/nutrients that can improve mitochondrial function and/or attenuate oxidative damage have been implicated in pd therapy. however, few studies have evaluated the preventative effects of a combination of mitochondrial antioxidants/nutrients against pd, and even fewer have sought to optimize the doses of the combined agents. the present study examined the preventative effects of two mitochondrial antioxidant/nutrients, r-alpha-lipoic acid (la) and acetyl-l-carnitine (alc), in a chronic rotenone-induced cellular model of pd. we demonstrated that 4-week pretreatment with la and/or alc effectively protected sk-n-mc human neuroblastoma cells against rotenone-induced mitochondrial dysfunction, oxidative damage and accumulation of alpha-synuclein and ubiquitin. most notably, we found that when combined, la and alc worked at 100-1000-fold lower concentrations than they did individually. we also found that pretreatment with combined la and alc increased mitochondrial biogenesis and decreased production of reactive oxygen species through the up-regulation of the peroxisome proliferator-activated receptor-gamma coactivator 1 alpha as a possible underlying mechanism. this study provides important evidence that combining mitochondrial antioxidant/nutrients at optimal doses might be an effective and safe prevention strategy for pd. |
| WOS关键词 | AGE-ASSOCIATED MITOCHONDRIAL ; OXIDATIVE STRESS ; OLD RATS ; COGNITIVE DYSFUNCTION ; COENZYME Q(10) ; 2 PARTS ; CELLS ; DECAY ; BRAIN ; NEURODEGENERATION |
| WOS研究方向 | Cell Biology ; Research & Experimental Medicine |
| WOS类目 | Cell Biology ; Medicine, Research & Experimental |
| 语种 | 英语 |
| WOS记录号 | WOS:000275639700019 |
| 出版者 | WILEY-BLACKWELL |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2406768 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Liu, Jiankang |
| 作者单位 | 1.Xi An Jiao Tong Univ, Inst Mitochondrial Biol & Med, Sch Life Sci & Technol, Xian 710049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 4.Second Mil Med Univ, Dept Biochem, Shanghai, Peoples R China 5.Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA USA |
| 推荐引用方式 GB/T 7714 | Zhang, Hongyu,Jia, Haiqun,Liu, Jianghai,et al. Combined r-alpha-lipoic acid and acetyl-l-carnitine exerts efficient preventative effects in a cellular model of parkinson's disease[J]. Journal of cellular and molecular medicine,2010,14(1-2):215-225. |
| APA | Zhang, Hongyu.,Jia, Haiqun.,Liu, Jianghai.,Ao, Ni.,Yan, Bing.,...&Liu, Jiankang.(2010).Combined r-alpha-lipoic acid and acetyl-l-carnitine exerts efficient preventative effects in a cellular model of parkinson's disease.Journal of cellular and molecular medicine,14(1-2),215-225. |
| MLA | Zhang, Hongyu,et al."Combined r-alpha-lipoic acid and acetyl-l-carnitine exerts efficient preventative effects in a cellular model of parkinson's disease".Journal of cellular and molecular medicine 14.1-2(2010):215-225. |
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来源：中国科学院大学
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