Nogo-66 regulates nanog expression through stat3 pathway in murine embryonic stem cells
文献类型：期刊论文
| 作者 | Gao, Yuan1,2; Wang, Bin1; Xiao, Zhifeng1; Chen, Bing1; Han, Jin1; Wang, Xia1; Zhang, Jing1; Gao, Shaorong3; Zhao, Yannan1; Dai, Jianwu1 |
| 刊名 | Stem cells and development
 |
| 出版日期 | 2010 |
| 卷号 | 19期号:1页码:53-60 |
| ISSN号 | 1547-3287 |
| DOI | 10.1089/scd.2008.0357 |
| 通讯作者 | Dai, jianwu(jwdai@genetics.ac.cn) |
| 英文摘要 | Homeodomain transcription factor nanog plays a critical role in maintaining murine embryonic stem (es) cells pluripotency. however, its expression regulation largely remains unknown. in this study we show that nogo receptor (ngr) participates in the regulation of nanog expression via stat3 pathway. activation of ngr results in the phosphorylation of stat3 and increases expression levels of nanog mrna and protein, which inhibits differentiation of embryoid bodies. this up-regulation of nanog can be abolished by ngr inhibitor pi-plc and nep1-40, or phospho-stat3 inhibitor ag490 and rapamycin. immunofluorescence assay demonstrates that ngr and its ligand nogo-a/b exist on mouse blastocysts and cultured es cells, suggesting ngr might play a role in early embryo development. |
| WOS关键词 | SELF-RENEWAL ; TRANSCRIPTIONAL NETWORKS ; AXONAL REGENERATION ; MOUSE EMBRYOS ; ASY/NOGO-B ; PLURIPOTENCY ; DIFFERENTIATION ; PROTEIN ; INHIBITOR ; IDENTIFICATION |
| WOS研究方向 | Cell Biology ; Hematology ; Research & Experimental Medicine ; Transplantation |
| WOS类目 | Cell & Tissue Engineering ; Hematology ; Medicine, Research & Experimental ; Transplantation |
| 语种 | 英语 |
| WOS记录号 | WOS:000273675300007 |
| 出版者 | MARY ANN LIEBERT INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2407111 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Dai, Jianwu |
| 作者单位 | 1.Chinese Acad Sci, Inst Genet & Dev Biol, Key Lab Mol Dev Biol, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100190, Peoples R China 3.Natl Inst Biol Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Yuan,Wang, Bin,Xiao, Zhifeng,et al. Nogo-66 regulates nanog expression through stat3 pathway in murine embryonic stem cells[J]. Stem cells and development,2010,19(1):53-60. |
| APA | Gao, Yuan.,Wang, Bin.,Xiao, Zhifeng.,Chen, Bing.,Han, Jin.,...&Dai, Jianwu.(2010).Nogo-66 regulates nanog expression through stat3 pathway in murine embryonic stem cells.Stem cells and development,19(1),53-60. |
| MLA | Gao, Yuan,et al."Nogo-66 regulates nanog expression through stat3 pathway in murine embryonic stem cells".Stem cells and development 19.1(2010):53-60. |
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来源：中国科学院大学
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