Overexpression of human cap10-like protein 46kd in t-acute lymphoblastic leukemia and acute myelogenous leukemia
文献类型：期刊论文
| 作者 | Wang, Youxin1; Chang, Naibai2; Zhang, Tian1; Liu, Hui2; Ma, Wenzhan1; Chu, Qiaoyun1; Lai, Qingxuan1; Liu, Lixin1; Wang, Wei1,3,4 |
| 刊名 | Genetic testing and molecular biomarkers
 |
| 出版日期 | 2010-02-01 |
| 卷号 | 14期号:1页码:127-133 |
| ISSN号 | 1945-0265 |
| DOI | 10.1089/gtmb.2009.0145 |
| 通讯作者 | Wang, wei(wei6014@gucas.ac.cn) |
| 英文摘要 | Aims: we earlier identified a novel gene human cap10-like protein 46kd (hclp46) from human acute myelogenous leukemia (aml) transformed from myelodysplastic syndrome cd34(+) cells, but the function of this gene remains unclear. in this study, a real-time polymerase chain reaction-based assay was developed to quantify expression of hclp46 in the peripheral blood of aml and t-acute lymphoblastic leukemia (t-all) primary samples and in six leukemic cell lines. also, we investigated expression of cdkn2a/b and the apoptosis in u937 cells when hclp46 is downregulated in vitro. results: our findings showed that hclp46 was overexpressed in aml, t-all, and the leukemic cell lines. suppressing hclp46 overexpression had no effect on expression of cdkn2a/b and apoptosis of u937 cells. conclusion: considering that hclp46 has the capability of modifying the notch pathway, our finding adds weight to the importance of notch signaling in hematopoiesis and suggests that overexpression of hclp46 might be an early event in the pathogenesis of aml and t-all. |
| WOS关键词 | ACUTE MYELOID-LEUKEMIA ; PRIMITIVE HEMATOPOIETIC-CELL ; LYMPHOMA-CELLS ; NOTCH ; GENE ; GLYCOSYLATION ; EXPRESSION ; MYELOPOIESIS ; INTEGRATION ; DROSOPHILA |
| WOS研究方向 | Biochemistry & Molecular Biology ; Genetics & Heredity |
| WOS类目 | Biochemistry & Molecular Biology ; Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000274422700021 |
| 出版者 | MARY ANN LIEBERT INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2407812 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, Wei |
| 作者单位 | 1.Chinese Acad Sci, Coll Life Sci, Grad Univ, Beijing 100049, Peoples R China 2.Beijing Hosp, Dept Hematol, Beijing, Peoples R China 3.Capital Med Univ, Sch Publ Hlth & Family Med, Beijing, Peoples R China 4.Edith Cowan Univ, Ctr Human Genet, Perth, WA, Australia |
| 推荐引用方式 GB/T 7714 | Wang, Youxin,Chang, Naibai,Zhang, Tian,et al. Overexpression of human cap10-like protein 46kd in t-acute lymphoblastic leukemia and acute myelogenous leukemia[J]. Genetic testing and molecular biomarkers,2010,14(1):127-133. |
| APA | Wang, Youxin.,Chang, Naibai.,Zhang, Tian.,Liu, Hui.,Ma, Wenzhan.,...&Wang, Wei.(2010).Overexpression of human cap10-like protein 46kd in t-acute lymphoblastic leukemia and acute myelogenous leukemia.Genetic testing and molecular biomarkers,14(1),127-133. |
| MLA | Wang, Youxin,et al."Overexpression of human cap10-like protein 46kd in t-acute lymphoblastic leukemia and acute myelogenous leukemia".Genetic testing and molecular biomarkers 14.1(2010):127-133. |
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来源：中国科学院大学
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