中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Overexpression of human cap10-like protein 46kd in t-acute lymphoblastic leukemia and acute myelogenous leukemia

文献类型:期刊论文

作者Wang, Youxin1; Chang, Naibai2; Zhang, Tian1; Liu, Hui2; Ma, Wenzhan1; Chu, Qiaoyun1; Lai, Qingxuan1; Liu, Lixin1; Wang, Wei1,3,4
刊名Genetic testing and molecular biomarkers
出版日期2010-02-01
卷号14期号:1页码:127-133
ISSN号1945-0265
DOI10.1089/gtmb.2009.0145
通讯作者Wang, wei(wei6014@gucas.ac.cn)
英文摘要Aims: we earlier identified a novel gene human cap10-like protein 46kd (hclp46) from human acute myelogenous leukemia (aml) transformed from myelodysplastic syndrome cd34(+) cells, but the function of this gene remains unclear. in this study, a real-time polymerase chain reaction-based assay was developed to quantify expression of hclp46 in the peripheral blood of aml and t-acute lymphoblastic leukemia (t-all) primary samples and in six leukemic cell lines. also, we investigated expression of cdkn2a/b and the apoptosis in u937 cells when hclp46 is downregulated in vitro. results: our findings showed that hclp46 was overexpressed in aml, t-all, and the leukemic cell lines. suppressing hclp46 overexpression had no effect on expression of cdkn2a/b and apoptosis of u937 cells. conclusion: considering that hclp46 has the capability of modifying the notch pathway, our finding adds weight to the importance of notch signaling in hematopoiesis and suggests that overexpression of hclp46 might be an early event in the pathogenesis of aml and t-all.
WOS关键词ACUTE MYELOID-LEUKEMIA ; PRIMITIVE HEMATOPOIETIC-CELL ; LYMPHOMA-CELLS ; NOTCH ; GENE ; GLYCOSYLATION ; EXPRESSION ; MYELOPOIESIS ; INTEGRATION ; DROSOPHILA
WOS研究方向Biochemistry & Molecular Biology ; Genetics & Heredity
WOS类目Biochemistry & Molecular Biology ; Genetics & Heredity
语种英语
WOS记录号WOS:000274422700021
出版者MARY ANN LIEBERT INC
URI标识http://www.irgrid.ac.cn/handle/1471x/2407812
专题中国科学院大学
通讯作者Wang, Wei
作者单位1.Chinese Acad Sci, Coll Life Sci, Grad Univ, Beijing 100049, Peoples R China
2.Beijing Hosp, Dept Hematol, Beijing, Peoples R China
3.Capital Med Univ, Sch Publ Hlth & Family Med, Beijing, Peoples R China
4.Edith Cowan Univ, Ctr Human Genet, Perth, WA, Australia
推荐引用方式
GB/T 7714
Wang, Youxin,Chang, Naibai,Zhang, Tian,et al. Overexpression of human cap10-like protein 46kd in t-acute lymphoblastic leukemia and acute myelogenous leukemia[J]. Genetic testing and molecular biomarkers,2010,14(1):127-133.
APA Wang, Youxin.,Chang, Naibai.,Zhang, Tian.,Liu, Hui.,Ma, Wenzhan.,...&Wang, Wei.(2010).Overexpression of human cap10-like protein 46kd in t-acute lymphoblastic leukemia and acute myelogenous leukemia.Genetic testing and molecular biomarkers,14(1),127-133.
MLA Wang, Youxin,et al."Overexpression of human cap10-like protein 46kd in t-acute lymphoblastic leukemia and acute myelogenous leukemia".Genetic testing and molecular biomarkers 14.1(2010):127-133.

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来源:中国科学院大学

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