Design, synthesis and evaluation of a series of alkylsiloxane-bonded stationary phases for expanded supercritical fluid chromatography separations
文献类型：期刊论文
| 作者 | Fu, Qing1; Jiang, Dasen1; Xin, Huaxia1; Dai, Zhuoshun1; Cai, Jianfeng1; Ke, Yanxiong1; Jin, Yu1; Liang, Xinmiao1,2 |
| 刊名 | JOURNAL OF CHROMATOGRAPHY A
 |
| 出版日期 | 2019-05-24 |
| 卷号 | 1593页码:127-134 |
| 关键词 | Supercritical fluid chromatography Alkylsiloxane-bonded stationary phases Linear solvation energy relationship Selectivity Retention mechanism |
| ISSN号 | 0021-9673 |
| DOI | 10.1016/j.chroma.2019.01.069 |
| 通讯作者 | Jin, Yu(Jiny@ecust.edu.cn) |
| 英文摘要 | Supercritical fluid chromatography (SFC) today represents an alternative technique in analytical chemistry due to its obvious benefits in kinetic performance and its complementarity to liquid chromatography. In this paper, a series of alkylsiloxane-bonded stationary phases were synthesized and evaluated to expand their SFC applications. Five kinds of non-endcapped C8 stationary phases (C8-1 to C8-5) with increasing bonding density were synthesized, and the carbon content was 3.91%, 6.07%, 7.97%, 8.65% and 9.10% respectively. Retention mechanism of the C8 phases in SFC in SFC was investigated by the use of a linear solvation energy relationship (LSER) model. Results underlined a close relationship between the bonding density of alkyl chain and the dispersion and polar interactions of the stationary phase. Complementary evaluation was studied based on the calculation of vector angle (theta), and the widest theta of 123 degrees was found between silica and C8 with the highest bonding density. Selective diversity also existed between the two C8 phases with the highest and lowest bonding densities. In addition, the effect of modifier on the SFC mechanism was investigated. Modifiers (methanol, ethanol, isopropanol and acetonitrile) had insignificant influence on the dispersion interaction but they mainly affected the hydrogen bonding interaction by changing the LSER parameters a and b. Finally, C8 and silica columns were applied for separation of eight amide alkaloids of Piper kadsura. Silica provided better retention but limited selectivity while C8 can distinguish alkaloids different in alkyl chain, double bond and cis-trans structure. This research further contributed to demonstrate the potential of alkylsiloxane-bonded stationary phase in improving selectivity of SFC. (C) 2019 Elsevier B.V. All rights reserved. |
| WOS关键词 | REVERSED-PHASE ; MASS-SPECTROMETRY ; CLASSIFICATION ; RETENTION ; SELECTIVITY ; IMPROVE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000466620100015 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/165524]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Jin, Yu |
| 作者单位 | 1.East China Univ Sci & Technol, Sch Pharm, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Nat Med, Key Lab Separat Sci Analyt Chem, Dalian 116023, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu, Qing,Jiang, Dasen,Xin, Huaxia,et al. Design, synthesis and evaluation of a series of alkylsiloxane-bonded stationary phases for expanded supercritical fluid chromatography separations[J]. JOURNAL OF CHROMATOGRAPHY A,2019,1593:127-134. |
| APA | Fu, Qing.,Jiang, Dasen.,Xin, Huaxia.,Dai, Zhuoshun.,Cai, Jianfeng.,...&Liang, Xinmiao.(2019).Design, synthesis and evaluation of a series of alkylsiloxane-bonded stationary phases for expanded supercritical fluid chromatography separations.JOURNAL OF CHROMATOGRAPHY A,1593,127-134. |
| MLA | Fu, Qing,et al."Design, synthesis and evaluation of a series of alkylsiloxane-bonded stationary phases for expanded supercritical fluid chromatography separations".JOURNAL OF CHROMATOGRAPHY A 1593(2019):127-134. |
入库方式： OAI收割
来源：大连化学物理研究所
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