Self-Assembling Nanotubes Consisting of Rigid Cyclic gamma-Peptides
文献类型：期刊论文
| 作者 | Li, Liangchun1; Zhan, Hongmei2; Duan, Pengfei3; Liao, Jian2; Quan, Junming4; Hu, Yu2; Chen, Zhongzhu2; Zhu, Jin2; Liu, Minghua3; Wu, Yun-Dong4 |
| 刊名 | ADVANCED FUNCTIONAL MATERIALS
 |
| 出版日期 | 2012-07-24 |
| 卷号 | 22期号:14页码:3051-3056 |
| ISSN号 | 1616-301X |
| 关键词 | Cyclic ?-peptide Branched Eg Chain Nanotube Self-assembly |
| DOI | 10.1002/adfm.201200488 |
| 英文摘要 | Self-assembling cyclic peptide nanotubes (SPNs) have been extensively studied due to their potential applications in biology and material sciences. Cyclic ?-peptides, which have a larger conformational space, have received less attention than the cyclic a- and beta-peptides. The self-assembly of cyclic homo-?-tetrapeptide based on cis-3-aminocyclohexanecarboxylic acid (?-Ach) residues, which can be easily synthesized by a one-pot process is investigated. Fourier transform infrared (FTIR) and NMR analysis along with density functional theory (DFT) calculations indicate that the cyclic homo-?-tetrapeptide, with a non-planar conformation, can self-assemble into nanotubes through hydrogen-bond-mediated parallel stacking. Atomic force microscopy (AFM) and transmission electron microscopy (TEM) experiments reveal the formation of bundles of nanotubes in CH2Cl2/hexane, but individual nanotubes and bundles of only two nanotubes are obtained in water. The integration of TEG (triethylene glycol) monomethyl ether chains and cyclopeptide backbones may allow the control of width of single nanotubes. |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000306315200018 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/48227]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Li, Liangchun |
| 作者单位 | 1.Sichuan Univ, Minist & Dept Med Chem, Key Lab Drug Targeting Educ, W China Sch Pharm, Chengdu 610041, Peoples R China 2.Chinese Acad Sci, Chengdu Inst Organ Chem, Key Lab Asymmetr Synth & Chirotechnol Sichuan Pro, Chengdu 610041, Peoples R China 3.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China 4.Peking Univ, Sch Chem Biol & Biotechnol, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Liangchun,Zhan, Hongmei,Duan, Pengfei,et al. Self-Assembling Nanotubes Consisting of Rigid Cyclic gamma-Peptides[J]. ADVANCED FUNCTIONAL MATERIALS,2012,22(14):3051-3056. |
| APA | Li, Liangchun.,Zhan, Hongmei.,Duan, Pengfei.,Liao, Jian.,Quan, Junming.,...&Deng, Jingen.(2012).Self-Assembling Nanotubes Consisting of Rigid Cyclic gamma-Peptides.ADVANCED FUNCTIONAL MATERIALS,22(14),3051-3056. |
| MLA | Li, Liangchun,et al."Self-Assembling Nanotubes Consisting of Rigid Cyclic gamma-Peptides".ADVANCED FUNCTIONAL MATERIALS 22.14(2012):3051-3056. |
入库方式： OAI收割
来源：化学研究所
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