alpha-Glucosidase Inhibitory Activity of Polyphenols from the Burs of Castanea mollissima Blume
文献类型：期刊论文
| 作者 | Zhang, Jianwei1,3; Zhao, Shan1,4; Yin, Peipei1; Yan, Linlin1; Han, Jin1; Shi, Lingling1; Zhou, Xiaojing1; Liu, Yujun1; Ma, Chao1,2 |
| 刊名 | MOLECULES
 |
| 出版日期 | 2014-06-01 |
| 卷号 | 19期号:6页码:8373-8386 |
| 关键词 | Castanea Mollissima Blume Polyphenols Alpha-glucosidase Diabetic Ellagitannins |
| ISSN号 | 1420-3049 |
| DOI | 10.3390/molecules19068373 |
| 英文摘要 | Polyphenol extracts from the burs of Castanea mollissima Blume (CMPE) exhibited potential antioxidant and hypoglycemic activities. The alpha-glucosidase inhibitory activities of CMPE were assessed as a means of elucidating the mechanism behind its hypoglycemic activities. In vitro studies showed that CMPE significantly inhibited both yeast alpha-glucosidase, through a noncompetitive mode with an IC50 of 0.33 mu g/mL, and rat intestinal alpha-glucosidase. In vivo studies revealed that oral administration of CMPE at doses of 600 mg/kg significantly reduced postprandial blood glucose levels by 27.2% in normal rats following sucrose challenges. Gel permeation chromatography revealed that CMPE exhibited typical characteristics of high-molecular-mass polymers with mean (Mn) and weight (Mw) average molecular weights of 35.4 and 50.7 kDa, respectively, and a polydispersity (Mw/Mn) of 1.432. Acid hydrolysis analysis indicated the presence of ellagitannins. These data suggest that CMPE, enriched with ellagitannins, would be an efficacious dietary supplement for diabetes management through the inhibition of alpha-glucosidase. |
| 语种 | 英语 |
| WOS记录号 | WOS:000338586700090 |
| 出版者 | MDPI AG |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/51003]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Yujun |
| 作者单位 | 1.Beijing Forestry Univ, Coll Biol Sci & Biotechnol, Natl Engn Lab Tree Breeding, Beijing 100083, Peoples R China 2.Beijing Forestry Univ, Coll Biol Sci & Biotechnol, Beijing Key Lab Forest Food Proc & Safety, Beijing 100083, Peoples R China 3.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China 4.State Acad Forestry Adm, Beijing 102600, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Jianwei,Zhao, Shan,Yin, Peipei,et al. alpha-Glucosidase Inhibitory Activity of Polyphenols from the Burs of Castanea mollissima Blume[J]. MOLECULES,2014,19(6):8373-8386. |
| APA | Zhang, Jianwei.,Zhao, Shan.,Yin, Peipei.,Yan, Linlin.,Han, Jin.,...&Ma, Chao.(2014).alpha-Glucosidase Inhibitory Activity of Polyphenols from the Burs of Castanea mollissima Blume.MOLECULES,19(6),8373-8386. |
| MLA | Zhang, Jianwei,et al."alpha-Glucosidase Inhibitory Activity of Polyphenols from the Burs of Castanea mollissima Blume".MOLECULES 19.6(2014):8373-8386. |
入库方式： OAI收割
来源：化学研究所
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