Molecular design of synthetic biodegradable polymers as cell scaffold materials
文献类型：期刊论文
| 作者 | Wang, SG; Wan, YQ; Cai, Q; He, B; Chen, WN |
| 刊名 | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| 出版日期 | 2004-03-01 |
| 卷号 | 20期号:2页码:191-194 |
| 关键词 | Aliphatic Polyester Modification Scaffold Cell Affinity Tissue Engineering |
| ISSN号 | 1005-9040 |
| 英文摘要 | Poly(lactic acid) and its copolymers are regarded as the most useful biomaterials. The good biocompatibility, biodegradability and mechanical properties of them make the synthetic biodegradable polymers have primary application to tissue engineering. The advantages and disadvantages of the synthetic biodegradable polymers as cell scaffold materials are evaluated. This article reviews the modification of polylactide-family aliphatic polymers to improve the cell affinity when the polymers are used as call scaffolds. We have developed four main approaches: to modify polyester cell scaffolds in combination of plasma treating and collagen coating; to introduce hydrophilic segments into aliphatic polyester backbones; to introduce pendant functional groups into polyester chains; to modify polyester with dextran. The results of the cell cultures prove that the approaches mentioned above have improved the cell affinity of the polyesters and have modulated cell function such as adhesion, proliferation and migration. |
| 语种 | 英语 |
| WOS记录号 | WOS:000220635600017 |
| 出版者 | HIGHER EDUCATION PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/55399]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, SG |
| 作者单位 | Chinese Acad Sci, Inst Chem, Key State Lab Polymer Phys & Chem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, SG,Wan, YQ,Cai, Q,et al. Molecular design of synthetic biodegradable polymers as cell scaffold materials[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2004,20(2):191-194. |
| APA | Wang, SG,Wan, YQ,Cai, Q,He, B,&Chen, WN.(2004).Molecular design of synthetic biodegradable polymers as cell scaffold materials.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,20(2),191-194. |
| MLA | Wang, SG,et al."Molecular design of synthetic biodegradable polymers as cell scaffold materials".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 20.2(2004):191-194. |
入库方式： OAI收割
来源：化学研究所
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