Synthesis and cell affinity of functionalized poly(L-lactide-co-beta-malic acid) with high molecular weight
文献类型：期刊论文
| 作者 | He, B; Wan, YQ; Bei, JZ; Wang, SG |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2004-10-01 |
| 卷号 | 25期号:22页码:5239-5247 |
| 关键词 | Poly(L-lactide-co-beta-malic Acid) Biodegradable Polymer Cell Affinity Scaffold Functionalization |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2003.12.030 |
| 英文摘要 | A novel functionalized biodegradable poly(L-lactide-co-beta-benzyl malolactonate) (p-PLMA) with high molecular weight was synthesized through ring-opening copolymerization. Three p-PLMA copolymers with different beta-benzyl malolactonate content were synthesized. The molecular weight (M-w) and tensile strength of the copolymer with 4 mol% beta-benzyl malolactonate content were 179,800 and 19.0 MPa respectively, the molecular weight (M-w) and tensile strength of p-PLMA decreased with beta-benzyl malolactonate content increasing. The hydrophilicity of the de-protected product: Poly(L-lactide-co-beta-malic acid) (d-PLMA) increased with malic acid content increasing. The results, of 3T3 mice fibroblasts cultivated on d-PLMA films showed that the cell adhesion on d-PLMA was better than that of PLLA and the cell attached efficiency of d-PLMA with 8 mol% malic acid content was the highest. The cells grew well both on the surface and inside of d-PLMA scaffolds. The cell affinity of d-PLMA was better than that of PLLA. (C) 2003 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000221366800003 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/55501]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, SG |
| 作者单位 | Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, B,Wan, YQ,Bei, JZ,et al. Synthesis and cell affinity of functionalized poly(L-lactide-co-beta-malic acid) with high molecular weight[J]. BIOMATERIALS,2004,25(22):5239-5247. |
| APA | He, B,Wan, YQ,Bei, JZ,&Wang, SG.(2004).Synthesis and cell affinity of functionalized poly(L-lactide-co-beta-malic acid) with high molecular weight.BIOMATERIALS,25(22),5239-5247. |
| MLA | He, B,et al."Synthesis and cell affinity of functionalized poly(L-lactide-co-beta-malic acid) with high molecular weight".BIOMATERIALS 25.22(2004):5239-5247. |
入库方式： OAI收割
来源：化学研究所
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