Evaluation of biodegradable synthetic scaffold coated on arterial prostheses implanted in rat subcutaneous tissue
文献类型：期刊论文
| 作者 | Wang, ZX; Wang, SG; Marois, Y; Guidoin, R; Zhang, Z |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2005-12-01 |
| 卷号 | 26期号:35页码:7387-7401 |
| 关键词 | Biodegradable Polymers Vascular Prostheses Scaffold Sealant Implant |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2005.05.058 |
| 英文摘要 | Polyester arterial prostheses impregnated with various synthetic biodegradable materials and with gelatin were implanted subcutaneously in rats for 3-180 days. The inflammation was assessed by quantifying the activity of alkaline phosphatase and by histology. The degradation of the scaffold materials was determined by scanning electron microscopy (SEM), size exclusion chromatography (SEC), and differential scanning calorimetry (DSC). The alkaline phosphatase activity induced by the polymer-impregnated grafts was similar to that induced by the non-impregnated controls during most of the post-implantation periods. Histological studies revealed that the acute inflammatory response was moderate to mild and was similar for all types of specimens, except for the gelatin-impregnated grafts that induced a severe acute inflammation during the first 2 weeks post-implantation. At 4 and 6 months, significant disintegration of the scaffold was observed, accompanied by enhanced tissue infiltration and a reactivation of the acute inflammatory phase. Linear and exponential degradation rates of the synthetic polymers were described. The relative degradation rates of the biodegradable polymers were ranked as following: PLLACL > PDLLA > PLLA > PCEL. In conclusion, biodegradable polymers may provide an option as sealant/scaffolding materials for vascular prosthesis. It is suggested that the degradation rate of the polymer scaffolding materials should be higher to achieve early healing while without inducing strong inflammation. (c) 2005 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000231750200020 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/57195]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhang, Z |
| 作者单位 | 1.Univ Laval, Dept Chirurg, Quebec City, PQ G1K 7I4, Canada 2.CHU Laval, Hop St Francois, Ctr Rech, Quebec City, PQ G1L 3L5, Canada 3.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, ZX,Wang, SG,Marois, Y,et al. Evaluation of biodegradable synthetic scaffold coated on arterial prostheses implanted in rat subcutaneous tissue[J]. BIOMATERIALS,2005,26(35):7387-7401. |
| APA | Wang, ZX,Wang, SG,Marois, Y,Guidoin, R,&Zhang, Z.(2005).Evaluation of biodegradable synthetic scaffold coated on arterial prostheses implanted in rat subcutaneous tissue.BIOMATERIALS,26(35),7387-7401. |
| MLA | Wang, ZX,et al."Evaluation of biodegradable synthetic scaffold coated on arterial prostheses implanted in rat subcutaneous tissue".BIOMATERIALS 26.35(2005):7387-7401. |
入库方式： OAI收割
来源：化学研究所
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