Effects of lunar dust simulant on cardiac function and fibrosis in rats
文献类型：期刊论文
| 作者 | He, Shuangxi1; Yin, Quanling6; Su, Yan6; Zhang, Xiaoping2,5; Liu JG(刘金国)4 ; Zhang, Lu3; Sun Y(孙燕)4,5,6
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| 刊名 | TOXICOLOGY RESEARCH
 |
| 出版日期 | 2019 |
| 卷号 | 8期号:4页码:499-508 |
| ISSN号 | 2045-452X |
| 产权排序 | 1 |
| 英文摘要 | The objective of this study was to investigate the effects of lunar dust simulant (LDS) on cardiac function and fibrosis. In an in vivo experiment, after 3 weeks of exposure, electrocardiography (ECG) and histopathological and immunohistochemical analyses of the cardiac tissue were performed. Systemic inflammatory markers and genes and proteins associated with cardiac tissue fibrosis were examined. In an in vitro experiment, fibrosis-related factors were detected in H9c2 cells by western blot and the mechanism of myocardial fibrosis by LDS exposure was explored. LDS exposure significantly altered heart rate indicators, implying altered cardiac and autonomic system functions. LDS dose-dependently increased the type and number of ECG abnormalities, and increased serum inflammatory factors. In addition, pathological changes in the myocardial tissue were observed through hematoxylin and eosin, Masson, and immunohistochemical staining; the expression of genes and proteins related to fibrosis in the myocardial tissue was also altered. These findings indicate that LDS exposure causes systemic inflammatory lesions that affect autonomic function, leading to inflammatory myocardial fibrosis. And its mechanisms involve the mediation of the nuclear factor-E2-related factor (Nrf2)/ nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) redox balance. |
| WOS关键词 | HEART-RATE-VARIABILITY ; HUMAN EXPOSURE LEVELS ; OXIDATIVE STRESS ; INFLAMMATION ; INHALATION ; TOXICITY |
| 资助项目 | Department of Science and Technology of Liaoning Province[20170520437] ; Open Projects Funding of Lunar and Planetary Science Laboratory, MUST Partner Laboratory of Key Laboratory of Lunar and Deep Space Exploration, CAS (Macau FDCT)[119/2017/A3] ; National Natural Science Foundation of China[51775541] ; Science and Technology Development Fund (FDCT) of Macau[020/2014/A1] |
| WOS研究方向 | Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000474305500010 |
| 资助机构 | Department of Science and Technology of Liaoning Province ; Open Projects Funding of Lunar and Planetary Science Laboratory, MUST Partner Laboratory of Key Laboratory of Lunar and Deep Space Exploration, CAS (Macau FDCT) ; National Natural Science Foundation of China ; Science and Technology Development Fund (FDCT) of Macau |
| 源URL | [http://ir.sia.cn/handle/173321/25331]  |
| 专题 | 沈阳自动化研究所_空间自动化技术研究室 |
| 通讯作者 | Sun Y(孙燕) |
| 作者单位 | 1.China Astronaut Research and Training Center, Beijing 100094, China 2.Lunar and Planetary Science Laboratory, Macau University of Science and Technology, Macau, China 3.Key Laboratory of Space Utilization, Technology and Engineering Center for Space Utilization, Chinese Academy of Sciences, Beijing 100094, China 4.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China 5.Lunar and Planetary Science Laboratory, MUST-Partner Laboratory of Key Laboratory of Lunar and Deep Space Exploration, CAS, China 6.College of Basic Medical Sciences, Shenyang Medical College, Shenyang 110034, China |
| 推荐引用方式 GB/T 7714 | He, Shuangxi,Yin, Quanling,Su, Yan,et al. Effects of lunar dust simulant on cardiac function and fibrosis in rats[J]. TOXICOLOGY RESEARCH,2019,8(4):499-508. |
| APA | He, Shuangxi.,Yin, Quanling.,Su, Yan.,Zhang, Xiaoping.,Liu JG.,...&Sun Y.(2019).Effects of lunar dust simulant on cardiac function and fibrosis in rats.TOXICOLOGY RESEARCH,8(4),499-508. |
| MLA | He, Shuangxi,et al."Effects of lunar dust simulant on cardiac function and fibrosis in rats".TOXICOLOGY RESEARCH 8.4(2019):499-508. |
入库方式： OAI收割
来源：沈阳自动化研究所
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