Theoretical substantiation of biological efficacy enhancement for beta-delayed particle decay C-9 beam: A Monte Carlo study in combination with analysis with the local effect model approach
文献类型：期刊论文
| 作者 | Tian, Liheng1,2,3; Li, Qiang1,2; Liu, Xinguo1,2; Dai, Zhongying1,2; Fu, Tingyan1,2; He, Pengbo1,2; Yan, Yuanlin1,2,3; Ma, Yuanyuan1,2,3; Huang, Qiyan1,2,3 |
| 刊名 | MEDICAL PHYSICS
 |
| 出版日期 | 2016-03-01 |
| 卷号 | 43期号:3页码:1200-1211 |
| 关键词 | heavy ion cancer therapy radioactive C-9 beam beta-delayed particle decay RBE enhancement clustered damage |
| ISSN号 | 0094-2405 |
| DOI | 10.1118/1.4941310 |
| 通讯作者 | Li, Qiang(liqiang@impcas.ac.cn) |
| 英文摘要 | Purpose: To improve the efficacy of heavy ion therapy, beta-delayed particle decay C-9 beam as a double irradiation source for cancer therapy has been proposed. The authors' previous experiment showed that relative biological effectiveness (RBE) values at the depths around the Bragg peak of a C-9 beam were enhanced and compared to its stable counterpart C-12 beam. The purpose of this study was to explore the nature of the biological efficacy enhancement theoretically. Methods: A Monte Carlo simulation study was conducted in this study. First a simplified cell model was established so as to form a tumor tissue. Subsequently, the tumor tissue was imported into the Monte Carlo simulation software package GATE and then the tumor cells were virtually irradiated with comparable C-9 and C-12 beams, respectively, in the simulations. The transportation and particle deposition data of the C-9 and C-12 beams, derived from the GATE simulations, were analyzed with the authors' local effect model implementation so as to deduce cell survival fractions. Results: The particles emitted from the decay process of deposited C-9 particles around a cell nucleus increased the dose delivered to the nucleus and elicited clustered damages around the secondary particles' trajectories. Therefore, compared to the C-12 beam, the RBE value of the C-9 beam increased at the depths around their Bragg peaks. Conclusions: Collectively, the increased local doses and clustered damages due to the decayed particles emitted from deposited C-9 particles led to the RBE enhancement in contrast with the C-12 beam. Thus, the enhanced RBE effect of a C-9 beam for a simplified tumor model was shown theoretically in this study. (C) 2016 American Association of Physicists in Medicine. |
| 收录类别 | SCI |
| WOS关键词 | ION TRACK STRUCTURE ; STRAND BREAKS ; C-9-ION BEAM ; BRAGG PEAK ; THERAPY ; RADIOTHERAPY ; IRRADIATION ; CELLS ; DNA |
| WOS研究方向 | Radiology, Nuclear Medicine & Medical Imaging |
| WOS类目 | Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000373707100016 |
| 出版者 | AMER ASSOC PHYSICISTS MEDICINE AMER INST PHYSICS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2557994 |
| 专题 | 寒区旱区环境与工程研究所 |
| 通讯作者 | Li, Qiang |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 73000, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China 3.Univ Chinese Acad Sci, Sch Phys, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tian, Liheng,Li, Qiang,Liu, Xinguo,et al. Theoretical substantiation of biological efficacy enhancement for beta-delayed particle decay C-9 beam: A Monte Carlo study in combination with analysis with the local effect model approach[J]. MEDICAL PHYSICS,2016,43(3):1200-1211. |
| APA | Tian, Liheng.,Li, Qiang.,Liu, Xinguo.,Dai, Zhongying.,Fu, Tingyan.,...&Huang, Qiyan.(2016).Theoretical substantiation of biological efficacy enhancement for beta-delayed particle decay C-9 beam: A Monte Carlo study in combination with analysis with the local effect model approach.MEDICAL PHYSICS,43(3),1200-1211. |
| MLA | Tian, Liheng,et al."Theoretical substantiation of biological efficacy enhancement for beta-delayed particle decay C-9 beam: A Monte Carlo study in combination with analysis with the local effect model approach".MEDICAL PHYSICS 43.3(2016):1200-1211. |
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来源：寒区旱区环境与工程研究所
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