Zebrafish FGFR3 is a negative regulator of RLR pathway to decrease IFN expression
文献类型:期刊论文
作者 | Liu, Shu-Bo1,4; Lu, Long-Feng1; Lu, Xiao-Bing1,4; Li, Shun1; Zhang, Yong-An1,2,3 |
刊名 | FISH & SHELLFISH IMMUNOLOGY |
出版日期 | 2019-09-01 |
卷号 | 92期号:1页码:224-229 |
ISSN号 | 1050-4648 |
关键词 | FGFR3 Negative regulator Interferon TBK1 Zebrafish |
DOI | 10.1016/j.fsi.2019.06.002 |
英文摘要 | Fibroblast growth factor receptor (FGFR) 3 is one of the four distinct membrane-spanning tyrosine kinases required for proper skeletal development. In fish, the role of FGFR3 is still unclear. In this article, we reveal that zebrafish FGFR3 is a negative regulator of interferon (IFN) production in the innate immune response by suppressing the activity of TANK-binding kinase 1 (TBK1) in the process of virus infection. qPCR experiments demonstrate that the transcriptional level of cellular FGFR3 was upregulated by infection with spring viremia of carp virus (SVCV), indicating that FGFR3 might be involved in the process of host cell response to viral infection. Then, overexpression of FGFR3 significantly impeded the IFN promoter activity induced by a stimulator. In addition, the capabilities of a retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) system to activate IFN promoter were decreased during the overexpression of FGFR3. Subsequently, FGFR3 decreased the phosphorylation of interferon regulatory factor 3 (IRF3) and mediator of IRF3 activation (MITA) by TBK1. These findings suggest that zebrafish FGFR3 is a negative regulator of IFN by attenuating the kinase activity of TBK1, leading to the suppression of IFN expression. |
WOS关键词 | INNATE IMMUNE-RESPONSE ; IFN-PHI-1 PRODUCTION ; KINASE-ACTIVITY ; SPRING VIREMIA ; BONE MASS ; FISH ; PROTEIN ; ACHONDROPLASIA ; ACTIVATION ; MUTATION |
资助项目 | National Natural Science Foundation of China[31725026] ; National Natural Science Foundation of China[31502200] ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China[2018CFA011] ; Knowledge Innovation Program of the Chinese Academy of Sciences[Y65E01-1-501] |
WOS研究方向 | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
语种 | 英语 |
出版者 | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
WOS记录号 | WOS:000483634300027 |
资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province of China ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; Knowledge Innovation Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; 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源URL | [http://ir.ihb.ac.cn/handle/342005/33271] |
专题 | 水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文 |
通讯作者 | Li, Shun; Zhang, Yong-An |
作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, Wuhan, Hubei, Peoples R China 2.Huazhong Agr Univ, Coll Fisheries, State Key Lab Agr Microbiol, Wuhan, Hubei, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Shandong, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Liu, Shu-Bo,Lu, Long-Feng,Lu, Xiao-Bing,et al. Zebrafish FGFR3 is a negative regulator of RLR pathway to decrease IFN expression[J]. FISH & SHELLFISH IMMUNOLOGY,2019,92(1):224-229. |
APA | Liu, Shu-Bo,Lu, Long-Feng,Lu, Xiao-Bing,Li, Shun,&Zhang, Yong-An.(2019).Zebrafish FGFR3 is a negative regulator of RLR pathway to decrease IFN expression.FISH & SHELLFISH IMMUNOLOGY,92(1),224-229. |
MLA | Liu, Shu-Bo,et al."Zebrafish FGFR3 is a negative regulator of RLR pathway to decrease IFN expression".FISH & SHELLFISH IMMUNOLOGY 92.1(2019):224-229. |
入库方式: OAI收割
来源:水生生物研究所
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