Bi2S3-Tween 20 Nanodots Loading PI3K Inhibitor, LY294002, for Mild Photothermal Therapy of LoVo Cells In Vitro and In Vivo
文献类型：期刊论文
| 作者 | Gu, Z.; Song L(宋丽); Dong XH(董兴华); Zhu S(朱双); Yin WY(尹文艳) ; Zhang X(张潇); Gu ZJ(谷战军); Song, L.; Dong, X.; Zhu, S.
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| 刊名 | ADVANCED HEALTHCARE MATERIALS
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| 出版日期 | 2018 |
| 卷号 | 7期号:22页码:1800830 |
| 关键词 | Bi2S3-Tween 20 nanodots LY294002 mild photothermal therapy photothermal-resistant PI3K inhibitors |
| ISSN号 | 2192-2640 |
| DOI | 10.1002/adhm.201800830 |
| 文献子类 | Article |
| 英文摘要 | Although various types of photothermal agents are developed for photothermal cancer therapy, relatively few photothermal agents exhibit high tumor inhibition rate under relatively mild conditions. Herein, a multifunctional Bi2S3-Tween 20 nanoplatform loaded with PI3K inhibitor LY294002 is designed as a novel photothermal agent for inhibitor and photothermal synergistic therapy of tumors under mild photothermal therapy conditions. The LY294002 of PI3K inhibitor, after being loaded by Bi2S3-Tween 20 nanodots, exhibits greatly increased drug utilization and reduced side effects on normal tissues. In vivo, Bi2S3-Tween 20@LY294002 upon near-infrared 808 nm laser irradiation shows potent antitumor activity under relatively mild conditions (power density: 0.6 W cm(-2)). Moreover, the mechanism studies also demonstrate that Bi2S3-Tween 20@LY294002 potently kills LoVo cancer cells under low-power near-infrared light irradiation, by downregulating the expression of heat shock protein 70 (HSP70) so as to increase the sensitivity of tumor cell hyperthermia and activating BAX/BAK-regulated mitochondrial apoptosis pathway. The results demonstrate that the newly synthesized multifunctional nanoplatform paves a new avenue for accurate therapy of photothermal-resistant cancer. |
| 电子版国际标准刊号 | 2192-2659 |
| WOS关键词 | DRUG-DELIVERY ; CANCER ; NANOPARTICLES ; NANOSHEETS ; HYPERTHERMIA ; NANOSPHERES ; NANORODS ; 3-KINASE ; CARRIER ; AGENT |
| WOS研究方向 | Engineering ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000450785100009 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/287006]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_实验物理中心 |
| 通讯作者 | Gu ZJ(谷战军) |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Gu, Z.,Song L,Dong XH,et al. Bi2S3-Tween 20 Nanodots Loading PI3K Inhibitor, LY294002, for Mild Photothermal Therapy of LoVo Cells In Vitro and In Vivo[J]. ADVANCED HEALTHCARE MATERIALS,2018,7(22):1800830. |
| APA | Gu, Z..,宋丽.,董兴华.,朱双.,尹文艳.,...&Liu, X..(2018).Bi2S3-Tween 20 Nanodots Loading PI3K Inhibitor, LY294002, for Mild Photothermal Therapy of LoVo Cells In Vitro and In Vivo.ADVANCED HEALTHCARE MATERIALS,7(22),1800830. |
| MLA | Gu, Z.,et al."Bi2S3-Tween 20 Nanodots Loading PI3K Inhibitor, LY294002, for Mild Photothermal Therapy of LoVo Cells In Vitro and In Vivo".ADVANCED HEALTHCARE MATERIALS 7.22(2018):1800830. |
入库方式： OAI收割
来源：高能物理研究所
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