Effect of N-acetylcysteine on C-12(6+) ion Irradiation-induced Lymphocytes DNA Damages and Immunity Changes in Mice
文献类型：期刊论文
| 作者 | Xie, Yi1,2 ; Zhang, Hong1,2; Hao, Ji-Fang1,2; Qiu, Rong1,2
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| 刊名 | JOURNAL OF RADIATION RESEARCH
 |
| 出版日期 | 2009-11-01 |
| 卷号 | 50页码:567-571 |
| 关键词 | C-12(6+) heavy ion N-acetylcysteine DNA double-strand breaks Immunity acute effects |
| ISSN号 | 0449-3060 |
| DOI | 10.1269/jrr.09047 |
| 英文摘要 | The aims of present Study are to estimate the biological risks to the immunity of mice exposed to heavy ion radiation and to investigate the effect of N-acetylcysteine (NAC) on C-12(6+) ion irradiation-induced lymphocyte DNA damage. Results showed that in the brine group the levels of lymphocyte DNA damage and MN, thymocytes G(2)/M phase arrest and apoptosis percentages (except for activity of NK cells) were up at each time point. A time-response Curve for MN and DNA damage appeared in file NAC group. We found that whole-body C-12(6+) ion irradiation at a dose of 4 Gy Could: induce lymphocyte DNA double-strand breaks (DSBs); immunocytes DSBs may lead to acute effects oil immunity and 200 mg/kg NAC showed significant protection against radiation harm. |
| WOS关键词 | PERIPHERAL-BLOOD ; CELLS ; RADIATION ; CYTOKINES ; REPAIR ; ACID |
| 资助项目 | National Natural Science Foundation of China[10675151] ; National Natural Science Foundation of China[10835011] ; Key Scientific Technology Research Projects of Gansu Province[0702NKDA045] ; Key Scientific Technology Research Projects of Gansu Province[0801NKDA001] ; Science and technology brainstorm Project of Lanzhou[07-2-07] |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics ; Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000273131700011 |
| 出版者 | JAPAN RADIATION RESEARCH SOC |
| 资助机构 | National Natural Science Foundation of China ; Key Scientific Technology Research Projects of Gansu Province ; Science and technology brainstorm Project of Lanzhou |
| 源URL | [http://119.78.100.186/handle/113462/31028]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zhang, Hong |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Res Ctr Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China 2.Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, Yi,Zhang, Hong,Hao, Ji-Fang,et al. Effect of N-acetylcysteine on C-12(6+) ion Irradiation-induced Lymphocytes DNA Damages and Immunity Changes in Mice[J]. JOURNAL OF RADIATION RESEARCH,2009,50:567-571. |
| APA | Xie, Yi,Zhang, Hong,Hao, Ji-Fang,&Qiu, Rong.(2009).Effect of N-acetylcysteine on C-12(6+) ion Irradiation-induced Lymphocytes DNA Damages and Immunity Changes in Mice.JOURNAL OF RADIATION RESEARCH,50,567-571. |
| MLA | Xie, Yi,et al."Effect of N-acetylcysteine on C-12(6+) ion Irradiation-induced Lymphocytes DNA Damages and Immunity Changes in Mice".JOURNAL OF RADIATION RESEARCH 50(2009):567-571. |
入库方式： OAI收割
来源：近代物理研究所
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