EARLY EFFECTS OF LOW DOSE C-12(6+) ION OR X-RAY IRRADIATION ON PERIPHERAL BLOOD LYMPHOCYTES OF PATIENTS WITH ALIMENTARY TRACT CANCER
文献类型：期刊论文
| 作者 | Chen, Yingtai1,2,3; Chen, Xuezhong; Li, Yumin1; Zhang, Hong4; Xie, Yi; Zhang, Xiaowei5; Ren, Huizi; Wang, Yanling4; Liao, Shiqi; He, Mingyan |
| 刊名 | DOSE-RESPONSE
 |
| 出版日期 | 2011 |
| 卷号 | 9页码:356-368 |
| 关键词 | low dose irradiation C-12(6+) X-ray peripheral blood cells alimentary tract cancer |
| ISSN号 | 1559-3258 |
| DOI | 10.2203/dose-response.10-015.Chen |
| 英文摘要 | The aim of this study was to examine the early effects of low dose C-12(6+) irradiation or X-ray on peripheral blood lymphocytes (PBL) of patients with alimentary tract cancer and to explore mechanisms that may be involved in an antitumor immune response. We found that the percentage of T lymphocyte subsets, the mRNA expression levels of IL-2 and IFN-gamma in PBL, and their protein levels in supernatant were significantly increased 24 hours after exposure to low dose radiation. The effects were more pronounced in the group receiving 0.05Gy C-12(6+) ion irradiation than the group receiving X-ray irradiation. There was no significant change in the percentage of NK cell subsets and TNF-alpha production of PBL. Our study suggests that low dose irradiation could alleviate immune suppression caused by tumor burden and that the effect was more pronounced for 0.05Gy high linear energy transfer (LET) C-12(6+) irradiation. |
| WOS关键词 | TOTAL-BODY IRRADIATION ; NON-HODGKINS-LYMPHOMA ; TUMOR-INFILTRATING LYMPHOCYTES ; NECROSIS-FACTOR-ALPHA ; REGULATORY T-CELLS ; IONIZING-RADIATION ; ADAPTIVE RESPONSE ; INTERFERON-GAMMA ; LUNG-CANCER ; IFN-GAMMA |
| 资助项目 | National Institute of Health (NIH)[1D43TW008323-01] ; National Institute of Health (NIH)[1D43TW007864-01] ; National Science Foundation of China[30870364] |
| WOS研究方向 | Pharmacology & Pharmacy ; Radiology, Nuclear Medicine & Medical Imaging ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000295840900005 |
| 出版者 | INT DOSE-RESPONSE SOC |
| 资助机构 | National Institute of Health (NIH) ; National Science Foundation of China |
| 源URL | [http://119.78.100.186/handle/113462/33936]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Li, Yumin |
| 作者单位 | 1.Lanzhou Univ, Hosp 2, Dept Gen Surg, Lanzhou 730030, Gansu, Peoples R China 2.Lanzhou Univ, Sch Clin Med, Lanzhou 730030, Gansu, Peoples R China 3.Yale Univ, Sch Med, New Haven, CT 06520 USA 4.Chinese Acad Sci, Dept Radiol, Inst Modern Phys, Beijing 100864, Peoples R China 5.Lanzhou Univ, Hosp 1, Cent Lab, Lanzhou 730030, Gansu, Peoples R China 6.KUMC, Ctr Liver, Kansas City, MO USA |
| 推荐引用方式 GB/T 7714 | Chen, Yingtai,Chen, Xuezhong,Li, Yumin,et al. EARLY EFFECTS OF LOW DOSE C-12(6+) ION OR X-RAY IRRADIATION ON PERIPHERAL BLOOD LYMPHOCYTES OF PATIENTS WITH ALIMENTARY TRACT CANCER[J]. DOSE-RESPONSE,2011,9:356-368. |
| APA | Chen, Yingtai.,Chen, Xuezhong.,Li, Yumin.,Zhang, Hong.,Xie, Yi.,...&Zhang, Yawei.(2011).EARLY EFFECTS OF LOW DOSE C-12(6+) ION OR X-RAY IRRADIATION ON PERIPHERAL BLOOD LYMPHOCYTES OF PATIENTS WITH ALIMENTARY TRACT CANCER.DOSE-RESPONSE,9,356-368. |
| MLA | Chen, Yingtai,et al."EARLY EFFECTS OF LOW DOSE C-12(6+) ION OR X-RAY IRRADIATION ON PERIPHERAL BLOOD LYMPHOCYTES OF PATIENTS WITH ALIMENTARY TRACT CANCER".DOSE-RESPONSE 9(2011):356-368. |
入库方式： OAI收割
来源：近代物理研究所
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