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Time-Delay Effects on Constitutive Gene Expression

文献类型：期刊论文

作者Feng, Yan-Ling1; Dong, Jian-Min2; Wang, Dan1; Tang, Xu-Lei1
刊名COMMUNICATIONS IN THEORETICAL PHYSICS
出版日期2017-09-01
卷号68页码:357-360
关键词gene expression time delay Fano factor
ISSN号0253-6102
DOI10.1088/0253-6102/68/3/357
英文摘要The dynamics of constitutive gene expression with delayed mRNA degradation is investigated, where the intrinsic noise caused by the small number of reactant molecules is introduced. It is found that the oscillatory behavior claimed in previous investigations does not appear in the approximation of small time delay, and the steady state distribution still follows the Poisson law. Furthermore, we introduce the extrinsic noise induced by surrounding environment to explore the effects of this noise and time delay on the Fano factor. Based on a delay Langevin equation and the corresponding Fokker-Planck equation, the distribution of mRNA copy-number is achieved analytically. The time delay and extrinsic noise play similar roles in the gene expression system, that is, they are able to result in the deviation of the Fano factor from 1 evidently. The measured Fano factor for constitutive gene expression is slightly larger than 1, which is perhaps attributed to the time-delay effect.
WOS关键词STOCHASTIC RESONANCE ; NOISE ; OSCILLATOR ; NETWORKS ; SYSTEM ; MODEL ; CELL
资助项目National Natural Science Foundation of China[11405223] ; National Natural Science Foundation of China[81370970] ; Youth Innovation Promotion Association of Chinese Academy of Sciences
WOS研究方向Physics
语种英语
WOS记录号WOS:000410778700013
出版者IOP PUBLISHING LTD
资助机构National Natural Science Foundation of China ; Youth Innovation Promotion Association of Chinese Academy of Sciences
源URL[http://119.78.100.186/handle/113462/45655]  
专题中国科学院近代物理研究所
通讯作者Tang, Xu-Lei
作者单位1.Lanzhou Univ, Hosp 1, Lanzhou 730000, Gansu, Peoples R China
2.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Gansu, Peoples R China
推荐引用方式
GB/T 7714		 Feng, Yan-Ling,Dong, Jian-Min,Wang, Dan,et al. Time-Delay Effects on Constitutive Gene Expression[J]. COMMUNICATIONS IN THEORETICAL PHYSICS,2017,68:357-360.
APA Feng, Yan-Ling,Dong, Jian-Min,Wang, Dan,&Tang, Xu-Lei.(2017).Time-Delay Effects on Constitutive Gene Expression.COMMUNICATIONS IN THEORETICAL PHYSICS,68,357-360.
MLA Feng, Yan-Ling,et al."Time-Delay Effects on Constitutive Gene Expression".COMMUNICATIONS IN THEORETICAL PHYSICS 68(2017):357-360.

入库方式： OAI收割

来源：近代物理研究所

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