Curcumin ameliorates cognitive deficits heavy ion irradiation-induced learning and memory deficits through enhancing of Nrf2 antioxidant signaling pathways
文献类型：期刊论文
| 作者 | Xie, Yi1,2,3; Zhao, Qiu Yue1,2,3,4; Li, Hong Yan1,2,3,4; Zhou, Xin1,2,3; Liu, Yang1,2,3; Zhang, Hong1,2,3
|
| 刊名 | PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
 |
| 出版日期 | 2014-11-01 |
| 卷号 | 126页码:181-186 |
| 关键词 | Curcumin C-12(6+) Irradiation Oxidative Stress Cerebral Injuries Nrf2 Pathway Mice |
| ISSN号 | 0091-3057 |
| DOI | 10.1016/j.pbb.2014.08.005 |
| 文献子类 | Article |
| 英文摘要 | Oxidative stress is one of the major mechanisms implicated in carbon ion irradiation. Curcumin is a natural phenolic compound with impressive antioxidant properties. What's more, curcumin is recently proved to exert its effects partly radioprotection. In vivo, we investigated the protective effects of curcumin against C-12(6+) radiation-induced cerebral injury. Our results showed that 4Gy heavy ion radiation-induced spatial strategy and memory decline and reduction of brain superoxide dismutase (SOD) activity levels were all consistently improved by curcumin, and the augmentation of cerebral malonaldehyde (MDA) was lowered by curcumin. Furthermore, both the cerebral cells nuclear erythroid 2-related factor 2 (Nrf2) protein and three typically recognized Nrf2 downstream genes, NAD(P)H quinine oxidoreductase 1 (NQO1), heme oxygenase-1 (HO-1), and gamma-glutamyl cysteine synthetase (gamma-GCS) were consistently up-regulated in curcumin-pretreated mice. Our study confirmed the antagonistic roles of curcumin to counteract radiation-induced cerebral injury in vivo and suggested that the potent Nrf2 activation capability might be valuable for the protective effects of curcumin against radiation. This provides a potential useful radioprotection dietary component for human populations. (C) 2014 Elsevier Inc. All rights reserved. |
| WOS关键词 | HIPPOCAMPAL DENTATE GYRUS ; NEURODEGENERATIVE DISEASES ; INDUCED INHIBITION ; GAMMA-IRRADIATION ; OXIDATIVE DAMAGE ; RESPONSE ELEMENT ; SPACE RADIATION ; MICE ; NEUROGENESIS ; DYSFUNCTION |
| 语种 | 英语 |
| WOS记录号 | WOS:000345471200024 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.186/handle/113462/49233]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zhang, Hong |
| 作者单位 | 1.Chinese Acad Sci, Inst Modem Phys, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China 3.Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou 730000, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, Yi,Zhao, Qiu Yue,Li, Hong Yan,et al. Curcumin ameliorates cognitive deficits heavy ion irradiation-induced learning and memory deficits through enhancing of Nrf2 antioxidant signaling pathways[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2014,126:181-186. |
| APA | Xie, Yi,Zhao, Qiu Yue,Li, Hong Yan,Zhou, Xin,Liu, Yang,&Zhang, Hong.(2014).Curcumin ameliorates cognitive deficits heavy ion irradiation-induced learning and memory deficits through enhancing of Nrf2 antioxidant signaling pathways.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,126,181-186. |
| MLA | Xie, Yi,et al."Curcumin ameliorates cognitive deficits heavy ion irradiation-induced learning and memory deficits through enhancing of Nrf2 antioxidant signaling pathways".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 126(2014):181-186. |
入库方式： OAI收割
来源：近代物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。