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Effects of ionizing radiation and HLY78 on the zebrafish embryonic developmental toxicity

文献类型：期刊论文

作者Si, Jing1,2,3; Zhou, Rong1,2,3; Zhao, Baoquan4; Xie, Yi1,2,3; Gan, Lu1,2,3; Zhang, Jinhua1,2,3,5; Wang, Yupei1,2,3,5; Zhou, Xin1,2,3; Ren, Xiaotang7; Zhang, Hong1,2,3,6
刊名TOXICOLOGY
出版日期2019
卷号411页码:143-153
关键词Carbon ion Proton Developmental toxicity HLY78 Wnt signaling
ISSN号0300-483X
DOI10.1016/j.tox.2018.10.004
英文摘要The health-related effects of ionizing radiation on embryonic development and their underlying mechanisms are still unclear. The aim of this study was to investigate the role of Wnt signaling in mediating the developmental toxicity induced by heavy ion and proton radiation using zebrafish embryos. Zebrafish embryos were radiated with carbon ions or protons. HLY78, an activator of the Wnt signaling pathway, was added immediately after radiation. Carbon ion radiation induced a significant increase of mortality, and activating Wnt signaling using HLY78 after radiation significantly alleviated this stress. Both carbon ion and proton radiation significantly increased malformation rates and decreased hatching rates. Supplementation with HLY78 significantly reduced the effects induced by carbon ion radiation alone. After irradiation with carbon ions, embryos showed a significant decrease in heart rate, spontaneous movement, and locomotive behavior. The expression of apoptotic genes was significantly increased, while the expression of anti-apoptotic and Wnt-related genes was significantly decreased. Supplementation with HLY78 was able to reduce these effects. However, embryos irradiated with proton radiation did not show significant changes in the expression of Wnt-related genes. The results of this study improve our understanding of the mechanisms of carbon ion radiation-induced developmental toxicity, which potentially involves the inhibition of Wnt signaling.
WOS关键词DANIO-RERIO ; CELL PROLIFERATION ; ION RADIATION ; SPINAL-CORD ; X-RAY ; WNT ; EXPRESSION ; EXPOSURE ; GENE ; IRRADIATION
资助项目Ministry of science and technology national key R D project[2016YFC0904600] ; Key Program of National Natural Science Foundation of China[U1432248] ; National Natural Science Foundation of China[11605255] ; National Natural Science Foundation of China[11305226] ; National Natural Science Foundation of China[11505244] ; Scientific Technology Research Projects of Gansu Province[17JR5RA315] ; State Key Laboratory of Nuclear Physics and Technology, Peking University ; National Laboratory of Heavy Ion Accelerator in Lanzhou
WOS研究方向Pharmacology & Pharmacy ; Toxicology
语种英语
WOS记录号WOS:000456223100015
出版者ELSEVIER IRELAND LTD
资助机构Ministry of science and technology national key R D project ; Key Program of National Natural Science Foundation of China ; National Natural Science Foundation of China ; Scientific Technology Research Projects of Gansu Province ; State Key Laboratory of Nuclear Physics and Technology, Peking University ; National Laboratory of Heavy Ion Accelerator in Lanzhou
源URL[http://119.78.100.186/handle/113462/66600]  
专题中国科学院近代物理研究所
作者单位1.Chinese Acad Sci, Inst Modern Phys, Dept Radiat Med, Lanzhou 730000, Peoples R China
2.Inst Modern Phys, CAS Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China
3.Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou 730000, Peoples R China
4.Acad Mil Med Sci, Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
6.Gansu Wuwei Tumor Hosp, Wuwei, Peoples R China
7.Peking Univ, State Key Lab Nucl Phys & Technol, Beijing 100850, Peoples R China
推荐引用方式
GB/T 7714		 Si, Jing,Zhou, Rong,Zhao, Baoquan,et al. Effects of ionizing radiation and HLY78 on the zebrafish embryonic developmental toxicity[J]. TOXICOLOGY,2019,411:143-153.
APA Si, Jing.,Zhou, Rong.,Zhao, Baoquan.,Xie, Yi.,Gan, Lu.,...&Zhang, Hong.(2019).Effects of ionizing radiation and HLY78 on the zebrafish embryonic developmental toxicity.TOXICOLOGY,411,143-153.
MLA Si, Jing,et al."Effects of ionizing radiation and HLY78 on the zebrafish embryonic developmental toxicity".TOXICOLOGY 411(2019):143-153.

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来源：近代物理研究所

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