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Alleviation of pre-exposure of mouse brain with low-dose C-12(6+) ion or Co-60 gamma-ray on male reproductive endocrine damages induced by subsequent high-dose irradiation

文献类型：期刊论文

作者Liu, Bing; Zhang, Hong; Zhou, Qingming; Zhou, Guangming; Yuan, Zhigang; Li, Wenjian; Duan, Xin; Min, Fengling; Xie, Yi; Li, Xiaoda
刊名INTERNATIONAL JOURNAL OF ANDROLOGY
出版日期2006-12-01
卷号29期号:6页码:592-596
ISSN号0105-6263
关键词C-12(6+) heavy ion adaptive response irradiation low-dose pre-exposure male reproductive endocrine capacity mouse brain
DOI10.1111/j.1365-2605.2006.00698.x
英文摘要Irradiation has been widely reported to damage organisms by attacking on proteins, nucleic acid and lipids in cells. However, radiation hormesis after low-dose irradiation has become the focus of research in radiobiology in recent years. To investigate the effects of pre-exposure of mouse brain with low-dose C-12(6+) ion or Co-60 gamma (gamma)-ray on male reproductive endocrine capacity induced by subsequent high-dose irradiation, the brains of the B6C3F(1) hybrid strain male mice were irradiated with 0.05 Gy of C-12(6+) ion or Co-60 gamma-ray as the pre-exposure dose, and were then irradiated with 2 Gy as challenging irradiation dose at 4 h after pre-exposure. Serum pituitary gonadotropin hormones, follicle-stimulating hormone (FSH) and luteinizing hormone (LH), testosterone, testis weight, sperm count and shape were measured on the 35th day after irradiation. The results showed that there was a significant reduction in the levels of serum FSH, LH, testosterone, testis weight and sperm count, and a significant increase in sperm abnormalities by irradiation of the mouse brain with 2 Gy of C-12(6+) ion or Co-60 gamma-ray. Moreover, the effects were more obvious in the group irradiated by C-12(6+) ion than in that irradiated by Co-60 gamma-ray. Pre-exposure with low-dose C-12(6+) ion or Co-60 gamma-ray significantly alleviated the harmful effects induced by a subsequent high-dose irradiation.
WOS关键词ADAPTIVE RESPONSE ; SUPEROXIDE-DISMUTASE ; IONIZING-RADIATION ; HUMAN-LYMPHOCYTES ; MAMMALIAN-CELLS ; ABNORMALITIES ; RADIOTHERAPY ; INDUCTION ; SYSTEM
WOS研究方向Endocrinology & Metabolism
语种英语
出版者BLACKWELL PUBLISHING
WOS记录号WOS:000242194900004
公开日期2010-10-29
源URL[http://ir.imp.cas.cn/handle/113462/5497]  
专题近代物理研究所_近代物理研究所知识存储（2010之前）
近代物理研究所_生物物理研究室
通讯作者Zhang, Hong
作者单位Chinese Acad Sci, Inst Modern Phys, Dept Med Phys, Lanzhou 730000, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Bing,Zhang, Hong,Zhou, Qingming,et al. Alleviation of pre-exposure of mouse brain with low-dose C-12(6+) ion or Co-60 gamma-ray on male reproductive endocrine damages induced by subsequent high-dose irradiation[J]. INTERNATIONAL JOURNAL OF ANDROLOGY,2006,29(6):592-596.
APA Liu, Bing.,Zhang, Hong.,Zhou, Qingming.,Zhou, Guangming.,Yuan, Zhigang.,...&Li, Xiaoda.(2006).Alleviation of pre-exposure of mouse brain with low-dose C-12(6+) ion or Co-60 gamma-ray on male reproductive endocrine damages induced by subsequent high-dose irradiation.INTERNATIONAL JOURNAL OF ANDROLOGY,29(6),592-596.
MLA Liu, Bing,et al."Alleviation of pre-exposure of mouse brain with low-dose C-12(6+) ion or Co-60 gamma-ray on male reproductive endocrine damages induced by subsequent high-dose irradiation".INTERNATIONAL JOURNAL OF ANDROLOGY 29.6(2006):592-596.

入库方式： OAI收割

来源：近代物理研究所

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