Germ cell loss induced by C-12(6+) ion irradiation in young female mice
文献类型：期刊论文
| 作者 | Zhang, Hong ; Zhang, Xu; Yuan, Zhigang; Li, Xiaoda; Li, Wenjian; Zhou, Qingming; Min, Fengling; Xie, Yi; Liu, Bing; Duan, Xin
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| 刊名 | JOURNAL OF RADIATION RESEARCH
 |
| 出版日期 | 2006-06-01 |
| 卷号 | 47期号:2页码:131-134 |
| 关键词 | C-12(6+) heavy ion germ cell loss female mice |
| ISSN号 | 0449-3060 |
| 英文摘要 | The ovaries of Kun-Ming strain mice (3 weeks) were irradiated with different doses of C-12(6+) ion in the Bragg peak or the plateau region. At 10th day after irradiation, ovarian and uterine weights were measured: normal and atretic (identified with the oocyte to be degenerating or absent) primordial, primary and preantral follicles were identified in the largest cross-section of each ovary. Percentage (%) of normal follicles of each developmental stage of oogenesis was calculated. The data showed that compared to controls, there was a dose-related decrease in percentage of normal follicles in each developmental stage. And the weights of ovary and uterus were also reduced with doses of irradiation. Moreover, these effects were much more significant in the Bragg peak region and the region close to the Bragg peak than in the beam's entrance (the plateau region). Radiosensitivity varied in different follicle maturation stages. Primordial follicles, which are thought to be extremely sensitive to ionizing irradiation, were reduced by 86.6%, while primary and preantral follicles reduced only by 72.5% and 61.8% respectively, by exposure with 6 Gy of C-12(6+) ion in the Bragg peak region and the region close to the Bragg peak. The data suggested that due to their optimal depth-dose distribution in the Bragg peak region, heavy ions are ones of the best particles for radiotherapy of tumors located next of vital organs or/and surrounded by normal tissues, especially radiosensitive tissues such as gonads. |
| WOS关键词 | OOCYTE APOPTOSIS ; MOUSE OOCYTES ; IN-VITRO ; RADIATION ; FOLLICLES ; CHEMOTHERAPY ; RADIOTHERAPY ; EXPRESSION ; ATRESIA ; BCL-2 |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics ; Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000239836200004 |
| 出版者 | JAPAN RADIATION RESEARCH SOC |
| 公开日期 | 2010-10-29 |
| 源URL | [http://ir.imp.cas.cn/handle/113462/6155]  |
| 专题 | 近代物理研究所_近代物理研究所知识存储（2010之前） |
| 通讯作者 | Zhang, Hong |
| 作者单位 | 1.Lanzhou Univ, Dept Pathol, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Dept Med Phys, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Hong,Zhang, Xu,Yuan, Zhigang,et al. Germ cell loss induced by C-12(6+) ion irradiation in young female mice[J]. JOURNAL OF RADIATION RESEARCH,2006,47(2):131-134. |
| APA | Zhang, Hong.,Zhang, Xu.,Yuan, Zhigang.,Li, Xiaoda.,Li, Wenjian.,...&Duan, Xin.(2006).Germ cell loss induced by C-12(6+) ion irradiation in young female mice.JOURNAL OF RADIATION RESEARCH,47(2),131-134. |
| MLA | Zhang, Hong,et al."Germ cell loss induced by C-12(6+) ion irradiation in young female mice".JOURNAL OF RADIATION RESEARCH 47.2(2006):131-134. |
入库方式： OAI收割
来源：近代物理研究所
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