中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 近代物理研究所
  3. 中国科学院近代物理研究所
  4. 近代物理研究所知识存储（2010之前）
Melatonin modulates acute testicular damage induced by carbon ions in mice

文献类型：期刊论文

作者Liu, Yang1,2; Zhang, Hong1,3; Zhang, Luwei1,3; Zhang, Xu4; Xie, Yi1,3; Zhao, Weiping1,2
刊名PHARMAZIE
出版日期2009-10-01
卷号64期号:10页码:685-689
ISSN号0031-7144
DOI10.1691/ph.2009.9067
英文摘要The present study was performed to obtain evidence of the radioprotective function of melatonin at different administration levels on carbon ion-induced mouse testicular damage. Outbred Kun-Ming strain mice were divided into six groups, each composed of eight animals: control group, melatonin alone group, irradiation group and three melatonin plus irradiation-treated groups. An acute study was carried out to determine alterations in DNA-single strand break, cell apoptosis, and oxidative stress parameters as well as histopathology in mouse testis 24 h after whole-body irradiation with a single dose of 4 Gy Tie results showed that pre-treatment and post-treatment with high-dose melatonin (10 mg/kg) both significantly alleviated carbon ion-induced acute testicular damage, a greater radioprotective effect being observed in the pre-treatment group. On the other hand, low-dose melatonin (1 mg/kg) had a limited radioprotective effect on irradiation-induced degeneration and DNA lesions in mouse testis. Taken together, the data suggest that prophylactic treatment with a higher dose of melatonin is probably advisable to protect against the effects of heavy-ion irradiation.
WOS关键词RADIATION RISK-ASSESSMENT ; OXIDATIVE DNA-DAMAGE ; IONIZING-RADIATION ; RADIOBIOLOGY RELEVANT ; LIPID-PEROXIDATION ; MOUSE TESTIS ; IRRADIATION ; CELLS ; RATS ; SPERMATOCYTES
资助项目National Natural Science Foundation of China[10675151] ; National Natural Science Foundation of China[10835011] ; Key Scientific Technology Research Projects of Gansu Province[O702NKDA045] ; Key Scientific Technology Research Projects of Gansu Province[O801NKDA001] ; Scientific Technology Research Project of Lanzhou-Chinese Academy of Sciences[07-2-07]
WOS研究方向Pharmacology & Pharmacy ; Chemistry
语种英语
WOS记录号WOS:000271272600012
出版者GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH
资助机构National Natural Science Foundation of China ; Key Scientific Technology Research Projects of Gansu Province ; Scientific Technology Research Project of Lanzhou-Chinese Academy of Sciences
公开日期2010-10-29
源URL[http://ir.imp.cas.cn/handle/113462/6303]  
专题近代物理研究所_近代物理研究所知识存储（2010之前）
通讯作者Zhang, Hong
作者单位1.Chinese Acad Sci, Inst Modern Phys, Dept Med Phys, Lanzhou 73070, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
3.Lanzhou Univ, Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou 730000, Peoples R China
4.Lanzhou Univ, Dept Pathol, Lanzhou 730000, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Yang,Zhang, Hong,Zhang, Luwei,et al. Melatonin modulates acute testicular damage induced by carbon ions in mice[J]. PHARMAZIE,2009,64(10):685-689.
APA Liu, Yang,Zhang, Hong,Zhang, Luwei,Zhang, Xu,Xie, Yi,&Zhao, Weiping.(2009).Melatonin modulates acute testicular damage induced by carbon ions in mice.PHARMAZIE,64(10),685-689.
MLA Liu, Yang,et al."Melatonin modulates acute testicular damage induced by carbon ions in mice".PHARMAZIE 64.10(2009):685-689.

入库方式： OAI收割

来源：近代物理研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。