One New Pregnane Glycoside from the Seeds of Cultivated Brucea javanica
文献类型：期刊论文
| 作者 | Liu, Jie-Qing; Wang, Cui-Fang; Li, Xing-Yao; Chen, Jian-Chao; Li, Yan ; Qiu, Ming-Hua
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| 刊名 | ARCHIVES OF PHARMACAL RESEARCH
 |
| 出版日期 | 2011-08-01 |
| 卷号 | 34期号:8页码:1297-1300 |
| 关键词 | Brucea javanica Pregnane glycoside Antitumor activity Brusatol |
| ISSN号 | 0253-6269 |
| 通讯作者 | Qiu, MH (reprint author), Chinese Acad Sci, State Key Lab Photochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China |
| 英文摘要 | A new pregnane glycoside, named (20R)-O-(3)-beta-D-glucopyranosyl-(1 -> 2)-alpha-L-arabinopyranosyl-pregn-5-en-3 beta,20-diol (1), and seven known compounds, brusatol (2), bruceine B (3), bruceine D (4), yadanziolide A (5), bruceine E (6), yadanzioside G (7), and yadanzioside B (8), were isolated from the cultivated dry seeds of Brucea jauanica. The structure of 1 was elucidated on the basis of 1D- and 2D-NMR spectroscopic analyses. Their inhibitory effects on tumor cells were also tested. Compound 1 was slightly active against HL-60, SMMC-7721, A-549, and MCF-7 tumor cells. Compounds 2 and 3 demonstrated significant inhibitory activities against all tested cells. These results indicate that cultivated B. jauanica could replace the wild plant as an antitumor plant resource. |
| 学科主题 | Pharmacology & Pharmacy |
| 类目[WOS] | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | QUASSINOID GLYCOSIDES |
| 收录类别 | SCI |
| 资助信息 | Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China[P2008-ZZ05, P2010-ZZ14]; CAS[KSCX2-YW-G-038, 027, KSCX2-YW-R-194, 29, KZCX2-XB2-15-03] |
| 语种 | 英语 |
| WOS记录号 | WOS:000294789700011 |
| 公开日期 | 2012-04-10 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/5379]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | Chinese Acad Sci, State Key Lab Photochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Jie-Qing,Wang, Cui-Fang,Li, Xing-Yao,et al. One New Pregnane Glycoside from the Seeds of Cultivated Brucea javanica[J]. ARCHIVES OF PHARMACAL RESEARCH,2011,34(8):1297-1300. |
| APA | Liu, Jie-Qing,Wang, Cui-Fang,Li, Xing-Yao,Chen, Jian-Chao,Li, Yan,&Qiu, Ming-Hua.(2011).One New Pregnane Glycoside from the Seeds of Cultivated Brucea javanica.ARCHIVES OF PHARMACAL RESEARCH,34(8),1297-1300. |
| MLA | Liu, Jie-Qing,et al."One New Pregnane Glycoside from the Seeds of Cultivated Brucea javanica".ARCHIVES OF PHARMACAL RESEARCH 34.8(2011):1297-1300. |
入库方式： OAI收割
来源：昆明植物研究所
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