Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules
文献类型：期刊论文
| 作者 | Liu LQ(刘连庆) ; Li M(李密)
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2011 |
| 卷号 | 32期号:6页码:781-788 |
| 关键词 | Human ether-a-go-go related gene (hERG) ion channel long QT syndrome (LQTS) activator |
| ISSN号 | 1671-4083 |
| 产权排序 | 1 |
| 中文摘要 | Human ether-a-go-go related gene (hERG) potassium (K(+)) channels play a critical role in cardiac action potential repolarization. Mutations that reduce hERG conductance or surface expression may cause congenital long QT syndrome (LQTS). Moreover, the channels can be inhibited by structurally diverse small molecules, resulting in an acquired form of LQTS. Consequently, small molecules that increase the hERG current may be of value for treatment of LQTS. So far, nine hERG activators have been reported. The aim of this review is to discuss recent advances concerning the identification and action mechanism of hERG activators. |
| WOS标题词 | Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine |
| 类目[WOS] | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Chemistry ; Pharmacology & Pharmacy |
| 关键词[WOS] | LONG-QT SYNDROME ; ACQUIRED CARDIAC-ARRHYTHMIA ; K+ CHANNEL ; STRUCTURAL BASIS ; MECHANISMS ; THERAPY ; INACTIVATION ; MUTATIONS |
| 收录类别 | SCI ; CSCD |
| 资助信息 | This work was supported by National Natural Science Foundation of China grant 81072579 and open funds of State Key Laboratory of Robotics RLO201013. |
| 语种 | 英语 |
| WOS记录号 | WOS:000291304000015 |
| 公开日期 | 2012-05-29 |
| 源URL | [http://ir.sia.cn/handle/173321/7296]  |
| 专题 | 沈阳自动化研究所_机器人学研究室 |
| 推荐引用方式 GB/T 7714 | Liu LQ,Li M. Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules[J]. ACTA PHARMACOLOGICA SINICA,2011,32(6):781-788. |
| APA | Liu LQ,&Li M.(2011).Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules.ACTA PHARMACOLOGICA SINICA,32(6),781-788. |
| MLA | Liu LQ,et al."Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules".ACTA PHARMACOLOGICA SINICA 32.6(2011):781-788. |
入库方式： OAI收割
来源：沈阳自动化研究所
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