Intraperitoneal injection of extracted microcystins results in hypovolemia and hypotension in crucian carp (Carassius auratus)
文献类型:期刊论文
作者 | Li, Dapeng1,2; Xie, Ping1,2; Zhang, Xuezhen2; Zhao, Yanyan2 |
刊名 | TOXICON |
出版日期 | 2009-05-01 |
卷号 | 53期号:6页码:638-644 |
ISSN号 | 0041-0101 |
关键词 | Microcystins Fish Blood pressure Hemorrhage Shock |
通讯作者 | Ping, X, Chinese Acad Sci, Inst Hydrobiol, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Donghu S Rd 7, Wuhan 430072, Peoples R China |
中文摘要 | Circulatory responses of crucian carp injected intraperitoneally with extracted micro-cystins (MCs) were studied at sublethal and lethal doses (150 and 600 mu g MC kg(-1) body mass, respectively). Mean arterial blood pressure (MAP), heart rate, hematocrit (Hct), red blood cell (RBC) counts, and circulating blood volume (BV) were assayed at 0, 1, 3, 12, 24, and 48 h post-toxin administration. MAP decreased significantly in a dose-dependent manner over time. Within the 48-h test period, the lethal dose as well as the sublethal dose resulted in a steady decline of MAP without recovery. Heart rate significantly increased within 24 h post-injection as blood pressure significantly dropped, then showed a terminal decline to the control level. The dose-dependent decreases in BV and Hct were directly related to the drop in MAP. Intraperitoneal injection of a lethal dose of MCs led to hepatic and gill hemorrhage. Consequently, crucian carp given MCs suffered from hypovolemic hypotensive shock. (C) 2009 Elsevier Ltd. All rights reserved. |
英文摘要 | Circulatory responses of crucian carp injected intraperitoneally with extracted micro-cystins (MCs) were studied at sublethal and lethal doses (150 and 600 mu g MC kg(-1) body mass, respectively). Mean arterial blood pressure (MAP), heart rate, hematocrit (Hct), red blood cell (RBC) counts, and circulating blood volume (BV) were assayed at 0, 1, 3, 12, 24, and 48 h post-toxin administration. MAP decreased significantly in a dose-dependent manner over time. Within the 48-h test period, the lethal dose as well as the sublethal dose resulted in a steady decline of MAP without recovery. Heart rate significantly increased within 24 h post-injection as blood pressure significantly dropped, then showed a terminal decline to the control level. The dose-dependent decreases in BV and Hct were directly related to the drop in MAP. Intraperitoneal injection of a lethal dose of MCs led to hepatic and gill hemorrhage. Consequently, crucian carp given MCs suffered from hypovolemic hypotensive shock. (C) 2009 Elsevier Ltd. All rights reserved. |
学科主题 | Pharmacology & Pharmacy; Toxicology |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
类目[WOS] | Pharmacology & Pharmacy ; Toxicology |
研究领域[WOS] | Pharmacology & Pharmacy ; Toxicology |
关键词[WOS] | TROUT ONCORHYNCHUS-MYKISS ; CYCLIC PEPTIDE TOXIN ; RAINBOW-TROUT ; BIOCHEMICAL-CHARACTERIZATION ; CYPRINUS-CARPIO ; BLOOD-PRESSURE ; ORAL TOXICITY ; BROWN TROUT ; LR ; AERUGINOSA |
资助信息 | Huazhong Agricultural University ; National Basic Research Program of China [2008CB418101] |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000265358600007 |
公开日期 | 2010-10-13 |
源URL | [http://ir.ihb.ac.cn/handle/152342/7768] |
专题 | 水生生物研究所_中科院水生所知识产出(2009年前)_期刊论文 |
作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Wuhan 430072, Peoples R China 2.Huazhong Agr Univ, Coll Fishery, Minist Agr, Key Lab Freshwater Biodivers Conservat & Utilizat, Wuhan 430070, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Dapeng,Xie, Ping,Zhang, Xuezhen,et al. Intraperitoneal injection of extracted microcystins results in hypovolemia and hypotension in crucian carp (Carassius auratus)[J]. TOXICON,2009,53(6):638-644. |
APA | Li, Dapeng,Xie, Ping,Zhang, Xuezhen,&Zhao, Yanyan.(2009).Intraperitoneal injection of extracted microcystins results in hypovolemia and hypotension in crucian carp (Carassius auratus).TOXICON,53(6),638-644. |
MLA | Li, Dapeng,et al."Intraperitoneal injection of extracted microcystins results in hypovolemia and hypotension in crucian carp (Carassius auratus)".TOXICON 53.6(2009):638-644. |
入库方式: OAI收割
来源:水生生物研究所
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