中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Intraperitoneal injection of extracted microcystins results in hypovolemia and hypotension in crucian carp (Carassius auratus)

文献类型:期刊论文

作者Li, Dapeng1,2; Xie, Ping1,2; Zhang, Xuezhen2; Zhao, Yanyan2
刊名TOXICON
出版日期2009-05-01
卷号53期号:6页码:638-644
ISSN号0041-0101
关键词Microcystins Fish Blood pressure Hemorrhage Shock
通讯作者Ping, X, Chinese Acad Sci, Inst Hydrobiol, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Donghu S Rd 7, Wuhan 430072, Peoples R China
中文摘要Circulatory responses of crucian carp injected intraperitoneally with extracted micro-cystins (MCs) were studied at sublethal and lethal doses (150 and 600 mu g MC kg(-1) body mass, respectively). Mean arterial blood pressure (MAP), heart rate, hematocrit (Hct), red blood cell (RBC) counts, and circulating blood volume (BV) were assayed at 0, 1, 3, 12, 24, and 48 h post-toxin administration. MAP decreased significantly in a dose-dependent manner over time. Within the 48-h test period, the lethal dose as well as the sublethal dose resulted in a steady decline of MAP without recovery. Heart rate significantly increased within 24 h post-injection as blood pressure significantly dropped, then showed a terminal decline to the control level. The dose-dependent decreases in BV and Hct were directly related to the drop in MAP. Intraperitoneal injection of a lethal dose of MCs led to hepatic and gill hemorrhage. Consequently, crucian carp given MCs suffered from hypovolemic hypotensive shock. (C) 2009 Elsevier Ltd. All rights reserved.
英文摘要Circulatory responses of crucian carp injected intraperitoneally with extracted micro-cystins (MCs) were studied at sublethal and lethal doses (150 and 600 mu g MC kg(-1) body mass, respectively). Mean arterial blood pressure (MAP), heart rate, hematocrit (Hct), red blood cell (RBC) counts, and circulating blood volume (BV) were assayed at 0, 1, 3, 12, 24, and 48 h post-toxin administration. MAP decreased significantly in a dose-dependent manner over time. Within the 48-h test period, the lethal dose as well as the sublethal dose resulted in a steady decline of MAP without recovery. Heart rate significantly increased within 24 h post-injection as blood pressure significantly dropped, then showed a terminal decline to the control level. The dose-dependent decreases in BV and Hct were directly related to the drop in MAP. Intraperitoneal injection of a lethal dose of MCs led to hepatic and gill hemorrhage. Consequently, crucian carp given MCs suffered from hypovolemic hypotensive shock. (C) 2009 Elsevier Ltd. All rights reserved.
学科主题Pharmacology & Pharmacy; Toxicology
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]Pharmacology & Pharmacy ; Toxicology
关键词[WOS]TROUT ONCORHYNCHUS-MYKISS ; CYCLIC PEPTIDE TOXIN ; RAINBOW-TROUT ; BIOCHEMICAL-CHARACTERIZATION ; CYPRINUS-CARPIO ; BLOOD-PRESSURE ; ORAL TOXICITY ; BROWN TROUT ; LR ; AERUGINOSA
资助信息Huazhong Agricultural University ; National Basic Research Program of China [2008CB418101]
收录类别SCI
语种英语
WOS记录号WOS:000265358600007
公开日期2010-10-13
源URL[http://ir.ihb.ac.cn/handle/152342/7768]  
专题水生生物研究所_中科院水生所知识产出(2009年前)_期刊论文
作者单位1.Chinese Acad Sci, Inst Hydrobiol, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Wuhan 430072, Peoples R China
2.Huazhong Agr Univ, Coll Fishery, Minist Agr, Key Lab Freshwater Biodivers Conservat & Utilizat, Wuhan 430070, Peoples R China
推荐引用方式
GB/T 7714
Li, Dapeng,Xie, Ping,Zhang, Xuezhen,et al. Intraperitoneal injection of extracted microcystins results in hypovolemia and hypotension in crucian carp (Carassius auratus)[J]. TOXICON,2009,53(6):638-644.
APA Li, Dapeng,Xie, Ping,Zhang, Xuezhen,&Zhao, Yanyan.(2009).Intraperitoneal injection of extracted microcystins results in hypovolemia and hypotension in crucian carp (Carassius auratus).TOXICON,53(6),638-644.
MLA Li, Dapeng,et al."Intraperitoneal injection of extracted microcystins results in hypovolemia and hypotension in crucian carp (Carassius auratus)".TOXICON 53.6(2009):638-644.

入库方式: OAI收割

来源:水生生物研究所

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