Research progress on therapeutic targeting of quiescent cancer cells
文献类型：期刊论文
| 作者 | Zhang, Jinhua2,3,4; Si, Jing2,3,4 ; Gan, Lu2,3,4; Di, Cuixia2,3,4; Xie, Yi2,3,4; Sun, Chao2,3,4; Li, Hongyan2,3,4; Guo, Menghuan1; Zhang, Hong2,3,4
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| 刊名 | ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
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| 出版日期 | 2019 |
| 卷号 | 47期号:1页码:2810-2819 |
| 关键词 | Quiescence pharmacological intervention radiation response hypoxia BNCT |
| ISSN号 | 2169-1401 |
| DOI | 10.1080/21691401.2019.1638793 |
| 英文摘要 | Cellular quiescence (G0) is a sleep-like cellular state that allows cells to maintain the ability to re-enter and exit the proliferative cycle. Quiescent cancer cells are considered a therapeutic challenge since they are often resistant to conventional chemoradiotherapy resulting in disease progression and relapse. To date, the majority of published studies have focused on identifying molecules that target proliferating tumor cells while limited information is available on methods to target quiescent cancer cells. This review provides a summary of the relevant molecular mechanisms underlying quiescence maintenance and pharmacological interventions aimed at either eliminating this cancer cell subpopulation or indefinitely maintaining the quiescence state. Furthermore, the irradiation responses of quiescent cancer cells, in particular, the influence of manipulating intratumor hypoxia and radiation properties on radiosensitivity, are discussed. The main aim of this article is to provide a theoretical basis for the effective targeted killing of dormant tumor cells. |
| WOS关键词 | RADIATION-INDUCED DAMAGE ; LOCAL TUMOR RESPONSE ; CYCLE ARREST ; DOSE-RATE ; IN-VIVO ; PROTEASOME ; HYPOXIA ; PROLIFERATION ; INHIBITION ; KINASE |
| 资助项目 | Ministry of science and technology national key R D project[2018YFE0205100] ; National Natural Science Foundation of China[11675234] ; National Natural Science Foundation of China[11605255] ; National Natural Science Foundation of China[11875061] |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000474568400005 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 资助机构 | Ministry of science and technology national key R D project ; National Natural Science Foundation of China |
| 源URL | [http://119.78.100.186/handle/113462/133077]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Si, Jing; Zhang, Hong |
| 作者单位 | 1.Lanzhou Univ, Sch Pharm, Lanzhou, Gansu, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Dept Radiat Med, Lanzhou, Gansu, Peoples R China 3.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Gansu, Peoples R China 4.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Jinhua,Si, Jing,Gan, Lu,et al. Research progress on therapeutic targeting of quiescent cancer cells[J]. ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,2019,47(1):2810-2819. |
| APA | Zhang, Jinhua.,Si, Jing.,Gan, Lu.,Di, Cuixia.,Xie, Yi.,...&Zhang, Hong.(2019).Research progress on therapeutic targeting of quiescent cancer cells.ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,47(1),2810-2819. |
| MLA | Zhang, Jinhua,et al."Research progress on therapeutic targeting of quiescent cancer cells".ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY 47.1(2019):2810-2819. |
入库方式： OAI收割
来源：近代物理研究所
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