Prenatal stress disturbs hippocampal KIF17 and NR2B in spatial cognition in male offspring
文献类型：期刊论文
| 作者 | Zhao, Depeng3,4; Liu, Dan3,4; Chen, Xueyu5; Wang, Kai2; Zhang, Ai3,4; Kang, Jiuhong1; Zhou, Qian3,4; Duan, Tao3,4 |
| 刊名 | JOURNAL OF NEUROSCIENCE RESEARCH
 |
| 出版日期 | 2013-04 |
| 卷号 | 91期号:4页码:535-544 |
| ISSN号 | 0360-4012 |
| 关键词 | prenatal stress offspring cognition hippocampus KIF17 |
| DOI | 10.1002/jnr.23172 |
| 文献子类 | Article |
| 英文摘要 | Numerous studies have demonstrated that prenatal stress disturbs the hippocampal-mediated learning and memory processes in offspring. The underlying mechanisms for this effect, however, remain vague. It is well documented that N-methyl-D-aspartate (NMDA) receptors play a pivotal role in learning and memory, which are related to dynamically trafficking and regulating NMDA receptors by their response motor proteins. Over the past few years, increasing numbers of studies have elucidated that hippocampal-mediated learning and memory are regulated by KIF17 (kinesin superfamily motor protein 17), which specifically transports and regulates the NMDA receptor subunit NR2B in hippocampal neurons. The present study shows the influence of prenatal stress on KIF17 and NR2B expression and hippocampal NR2A/NR2B ratio partially reflecting function of KIF17, using mice as models. It was found that prenatal stress significantly decreased the hippocampal KIF17 and NR2B level in offspring at postnatal stages of 3 weeks and 9 weeks. Moreover, hippocampal KIF17 in the prenatally stressed pups continued to be weakened even after serial Morris water maze trainings, but not NR2B. Finally, the synaptic NR2A/NR2B level was upregulated in offspring exposed to prenatal stress, which revealed the dysfunction of KIF17. Thus, we conclude that prenatal stress leads to long-lasting deterioration of the expression and function of hippocampal KIF17 in offspring, which may be related to deficits of spatial cognition caused by prenatal stress. These data underpin the hypotheses that a physiopathology of neurodevelopmental origin in early life leads to defects in learning and memory in later life. (c) 2012 Wiley Periodicals, Inc. |
| WOS关键词 | MOTOR PROTEIN KIF17 ; NMDA-RECEPTOR ; SYNAPTIC PLASTICITY ; LEARNING-DEFICITS ; RESTRAINT STRESS ; MATERNAL STRESS ; FEMALE RATS ; INHIBITION ; IMPAIRMENT ; NEURONS |
| 资助项目 | National Natural Science Foundation of China[81170628] ; National Natural Science Foundation of China[81270759] ; Ministry of Education of the People's Republic of China[20110072110005] ; Shanghai Health Bureau[XBR2011064] ; Shanghai Health Bureau[2008008] ; Shanghai Science and Technology Commission[11140901900] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| 出版者 | WILEY-BLACKWELL |
| WOS记录号 | WOS:000314973400007 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277685]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Duan, Tao |
| 作者单位 | 1.Tongji Univ, Sch Life Sci & Technol, Shanghai Key Lab Signaling & Dis Res, Shanghai 20040, Peoples R China 2.Tongji Univ, Clin & Translat Res Ctr, Shanghai Matern & Infant Hosp 1, Sch Med, Shanghai 20040, Peoples R China; 3.Tongji Univ, Sch Med, Dept Obstet & Gynecol, Shanghai 20040, Peoples R China; 4.Tongji Univ, Dept Obstet, Shanghai Matern & Infant Hosp 1, Shanghai 20040, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhao, Depeng,Liu, Dan,Chen, Xueyu,et al. Prenatal stress disturbs hippocampal KIF17 and NR2B in spatial cognition in male offspring[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2013,91(4):535-544. |
| APA | Zhao, Depeng.,Liu, Dan.,Chen, Xueyu.,Wang, Kai.,Zhang, Ai.,...&Duan, Tao.(2013).Prenatal stress disturbs hippocampal KIF17 and NR2B in spatial cognition in male offspring.JOURNAL OF NEUROSCIENCE RESEARCH,91(4),535-544. |
| MLA | Zhao, Depeng,et al."Prenatal stress disturbs hippocampal KIF17 and NR2B in spatial cognition in male offspring".JOURNAL OF NEUROSCIENCE RESEARCH 91.4(2013):535-544. |
入库方式： OAI收割
来源：上海药物研究所
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