Anti-diabetic Effect of Punica granatum Flower Polyphenols Extract in Type 2 Diabetic Rats: Activation of Akt/GSK-3 beta and Inhibition of IRE1 alpha-XBP1 Pathways
文献类型：期刊论文
| 作者 | Tang, Dan2; Liu, Liu2,3; Ajiakber, Dildar3,4; Ye, Jianping1; Xu, Jianjun2,3; Xin, Xuelei2; Aisa, Haji Akber2 |
| 刊名 | FRONTIERS IN ENDOCRINOLOGY
 |
| 出版日期 | 2018-10-15 |
| 卷号 | 9 |
| 关键词 | type 2 diabetes mellitus Punica granatum L. flower anti-diabetic herb oral glucose tolerance test endoplasmic reticulum stress insulin resistance |
| ISSN号 | 1664-2392 |
| DOI | 10.3389/fendo.2018.00586 |
| 文献子类 | Article |
| 英文摘要 | Type 2 diabetes mellitus (T2DM) is the most common type of diabetes with more than hundreds of millions of patients worldwide. However, the medicines for treatment of T2DM are very limited. In China, Punica granatum L. flower (PGF) has been used as an anti-diabetic herb in the herbal medicine. The activity involves in improvement of insulin sensitivity. However, the underlying mechanism of action is elusive. The current study was designed to address this issue by investigating the effect of polyphenols extract of PGF in diabetic rats. A rat model was orally administrated with PGF polyphenols extract at doses of 50 and 100 mg/kg for 4 weeks. Insulin sensitivity was improved as indicated by oral glucose tolerance test (OGTT), insulin tolerance test (ITT) and homeostasis model assessment of insulin resistance (HOMA-IR). At the molecular level, insulin signaling activity was improved with an elevation in insulin-stimulated phosphorylation of insulin receptor substrate (IRS-1), Akt and GSK-3 beta. Endoplasmic reticulum (ER) stress signals including phosphorylation of inositol-requiring kinase1 (IRE1) and activation of X box binding protein (XBP-1) splicing were decreased by the PGF treatment. Expressions of IRE1 alpha, XBPs, and CHOP were all decreased by PGF. Blood lipid profile, liver glycogen content and antioxidant status were improved by PGF in the rats. The observations suggest that PGF is able to lower glucose levels in T2DM rats by improving the insulin resistance. The mechanism is likely related to the activation of Akt-GSK3 beta signaling pathway and inhibition of ER stress. |
| WOS关键词 | ENDOPLASMIC-RETICULUM STRESS ; UNFOLDED PROTEIN RESPONSE ; STREPTOZOTOCIN-TREATED RAT ; INSULIN-RESISTANCE ; OBESITY ; MODEL ; MELLITUS ; GLUCOSE ; ALPHA ; CELLS |
| 资助项目 | National Natural Science Foundation of China[U1703235] |
| WOS研究方向 | Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000447268700001 |
| 出版者 | FRONTIERS MEDIA SA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279532]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Xin, Xuelei; Aisa, Haji Akber |
| 作者单位 | 1.Louisisana State Univ, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA 2.Chinese Acad Sci, State Key Lab Basis Xinjiang Indigenous Med Plant, Xinjiang Tech Inst Phys & Chem, Urumqi, Peoples R China; 3.Univ Chinese Acad Sci, Beijing, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Tang, Dan,Liu, Liu,Ajiakber, Dildar,et al. Anti-diabetic Effect of Punica granatum Flower Polyphenols Extract in Type 2 Diabetic Rats: Activation of Akt/GSK-3 beta and Inhibition of IRE1 alpha-XBP1 Pathways[J]. FRONTIERS IN ENDOCRINOLOGY,2018,9. |
| APA | Tang, Dan.,Liu, Liu.,Ajiakber, Dildar.,Ye, Jianping.,Xu, Jianjun.,...&Aisa, Haji Akber.(2018).Anti-diabetic Effect of Punica granatum Flower Polyphenols Extract in Type 2 Diabetic Rats: Activation of Akt/GSK-3 beta and Inhibition of IRE1 alpha-XBP1 Pathways.FRONTIERS IN ENDOCRINOLOGY,9. |
| MLA | Tang, Dan,et al."Anti-diabetic Effect of Punica granatum Flower Polyphenols Extract in Type 2 Diabetic Rats: Activation of Akt/GSK-3 beta and Inhibition of IRE1 alpha-XBP1 Pathways".FRONTIERS IN ENDOCRINOLOGY 9(2018). |
入库方式： OAI收割
来源：上海药物研究所
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