Extending the Structural View of Class B GPCRs
文献类型：期刊论文
| 作者 | de Graaf, Chris9; Song, Gaojie10; Cao, Can1,11; Zhao, Qiang1,2,3,11 ; Wang, Ming-Wei1,4,5,6,11; Wu, Beili1,3,5,11; Stevens, Raymond C.5,7,8,10
|
| 刊名 | TRENDS IN BIOCHEMICAL SCIENCES
 |
| 出版日期 | 2017-12 |
| 卷号 | 42期号:12页码:946-960 |
| ISSN号 | 0968-0004 |
| DOI | 10.1016/j.tibs.2017.10.003 |
| 文献子类 | Review |
| 英文摘要 | The secretin-like class B family of G protein-coupled receptors (GPCRs) are key players in hormonal homeostasis. Recent structures of various receptors in complex with a variety of orthosteric and allosteric ligands provide fundamental new insights into the function and mechanism of class B GPCRs, including: (i) ligand-induced changes in the relative orientation of the extracellular and transmembrane receptor domains; (ii) intramolecular interaction networks that stabilize conformational changes to accommodate intracellular G protein binding; and (iii) allosteric modulation of receptor activation. This review provides a comprehensive analysis of the structural, biochemical, and pharmacological data on class B GPCRs for understanding ligand-receptor interaction and modulation mechanisms and assessing the potential implications for drug discovery for the secretin-like GPCR family. |
| WOS关键词 | GLUCAGON-LIKE PEPTIDE-1 ; PROTEIN-COUPLED-RECEPTOR ; CORTICOTROPIN-RELEASING-FACTOR ; 2ND TRANSMEMBRANE HELIX ; FACTOR TYPE-1 RECEPTOR ; CRYO-EM STRUCTURE ; CRYSTAL-STRUCTURE ; GLP-1 RECEPTOR ; PARATHYROID-HORMONE ; LIGAND-BINDING |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE LONDON |
| WOS记录号 | WOS:000415796000004 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272386]  |
| 专题 | 药物靶标结构与功能中心 中科院受体结构与功能重点实验室 新药研究国家重点实验室 国家新药筛选中心 |
| 通讯作者 | Stevens, Raymond C. |
| 作者单位 | 1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, CAS Ctr Excellence Biomacromol, Beijing 100101, Peoples R China; 4.Natl Ctr Drug Screening, 189 Guo Shou Jing Rd, Shanghai 201203, Peoples R China; 5.ShanghaiTech Univ, Sch Life Sci & Technol, 393 Hua Xia Zhong Rd, Shanghai 201210, Peoples R China; 6.Fudan Univ, Sch Pharm, 826 Zhangheng Rd, Shanghai 201203, Peoples R China; 7.Univ Southern Calif, Bridge Inst, Dept Chem, 3430 South Vermont Ave, Los Angeles, CA 90089 USA 8.Univ Southern Calif, Bridge Inst, Dept Biol Sci, 3430 South Vermont Ave, Los Angeles, CA 90089 USA; 9.Vrije Univ Amsterdam, Div Med Chem, Fac Sci, AIMMS, De Boelelaan 1108, NL-1081 HZ Amsterdam, Netherlands; 10.ShanghaiTech Univ, iHuman Inst, 393 Hua Xia Zhong Rd, Shanghai 201210, Peoples R China; |
| 推荐引用方式 GB/T 7714 | de Graaf, Chris,Song, Gaojie,Cao, Can,et al. Extending the Structural View of Class B GPCRs[J]. TRENDS IN BIOCHEMICAL SCIENCES,2017,42(12):946-960. |
| APA | de Graaf, Chris.,Song, Gaojie.,Cao, Can.,Zhao, Qiang.,Wang, Ming-Wei.,...&Stevens, Raymond C..(2017).Extending the Structural View of Class B GPCRs.TRENDS IN BIOCHEMICAL SCIENCES,42(12),946-960. |
| MLA | de Graaf, Chris,et al."Extending the Structural View of Class B GPCRs".TRENDS IN BIOCHEMICAL SCIENCES 42.12(2017):946-960. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。