Cp*Rh(III)-Catalyzed Directed C-H Methylation and Arylation of Quinoline N-Oxides at the C-8 Position
文献类型：期刊论文
| 作者 | Wang, Bao1,2,3; Li, Chunpu1,3; Liu, Hong1,2,3
|
| 刊名 | ADVANCED SYNTHESIS & CATALYSIS
 |
| 出版日期 | 2017-09-04 |
| 卷号 | 359期号:17页码:3029-3034 |
| 关键词 | Quinoline N-Oxides C-H Methylation Rhodium |
| ISSN号 | 1615-4150 |
| DOI | 10.1002/adsc.201700484 |
| 文献子类 | Article |
| 英文摘要 | Herein, we report a Cp*Rh(III)-catalyzed directed C-H methylation of quinoline N-oxides at the C-8 position using commercially available organotrifluoroborates as reagents. This method features perfect regioselectivity, relatively mild reaction conditions, and diverse functional group tolerance with good to excellent yields. Additionally, direct C-8 arylated quinoline N-oxides products could also be obtained under the same conditions. Preliminary mechanistic experiments were conducted and a possible mechanism was proposed. |
| WOS关键词 | CROSS-COUPLING REACTION ; BOND ACTIVATION ; BORONIC ACIDS ; MILD CONDITIONS ; FUNCTIONALIZATION ; ALKYLATION ; ALKYNES ; ARENES ; HETEROARENES ; DISCOVERY |
| 资助项目 | National Natural Science Foundation of China[81620108027] ; National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[91229204] ; National Natural Science Foundation of China[81220108025] ; National Natural Science Foundation of China[81602975] ; Major Project of Chinese National Programs for Fundamental Research and Development[2015CB910304] ; National S&T Major Projects[2014ZX09507002-001] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000408941200017 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272488]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Liu, Hong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Bao,Li, Chunpu,Liu, Hong. Cp*Rh(III)-Catalyzed Directed C-H Methylation and Arylation of Quinoline N-Oxides at the C-8 Position[J]. ADVANCED SYNTHESIS & CATALYSIS,2017,359(17):3029-3034. |
| APA | Wang, Bao,Li, Chunpu,&Liu, Hong.(2017).Cp*Rh(III)-Catalyzed Directed C-H Methylation and Arylation of Quinoline N-Oxides at the C-8 Position.ADVANCED SYNTHESIS & CATALYSIS,359(17),3029-3034. |
| MLA | Wang, Bao,et al."Cp*Rh(III)-Catalyzed Directed C-H Methylation and Arylation of Quinoline N-Oxides at the C-8 Position".ADVANCED SYNTHESIS & CATALYSIS 359.17(2017):3029-3034. |
入库方式： OAI收割
来源：上海药物研究所
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