C-H Trifluoromethylation of 2-Substituted/Unsubstituted Aminonaphthoquinones at Room Temperature with Bench-Stable (CF3SO2)(2)Zn: Synthesis and Antiproliferative Evaluation
文献类型：期刊论文
| 作者 | Li, Jing1,2 ; Zhang, Xiaofei1; Xiang, Haoyue1; Tong, Linjiang; Feng, Fang1; Xie, Hua1; Ding, Jian1; Yang, Chunhao1
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| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
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| 出版日期 | 2017-07-07 |
| 卷号 | 82期号:13页码:6795-6800 |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/acs.joc.7b00940 |
| 文献子类 | Article |
| 英文摘要 | A direct C-H trifluoromethylation of 2-amino1,4-naphthoquinone analogues is described. This reaction proceeds under mild conditions at open atmosphere, providing a range of CF3-containing naphthoquinones with good yield and functional group compatibility. All synthetic compounds were screened for antiproliferative activity against three human cancer cell lines. Notably, some of those trifluoromethyl analogs, such as 3a, 3g, 3j, and 3t, showed good antiproliferative profiles. |
| WOS关键词 | MEDICINAL CHEMISTRY ; SODIUM TRIFLUOROMETHANESULFINATE ; 1,4-NAPHTHOQUINONE DERIVATIVES ; PROTEASOME INHIBITORS ; GROWTH-INHIBITION ; ARYLBORONIC ACIDS ; FLUORINE ; AGENTS ; HETEROCYCLES ; FACILE |
| 资助项目 | SKLDR/SIMM[SIMM1601ZZ-03] ; Shanghai Sailing Program[1717E1423400] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000405358000029 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272569]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 国家新药筛选中心 |
| 通讯作者 | Yang, Chunhao |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Jing,Zhang, Xiaofei,Xiang, Haoyue,et al. C-H Trifluoromethylation of 2-Substituted/Unsubstituted Aminonaphthoquinones at Room Temperature with Bench-Stable (CF3SO2)(2)Zn: Synthesis and Antiproliferative Evaluation[J]. JOURNAL OF ORGANIC CHEMISTRY,2017,82(13):6795-6800. |
| APA | Li, Jing.,Zhang, Xiaofei.,Xiang, Haoyue.,Tong, Linjiang.,Feng, Fang.,...&Yang, Chunhao.(2017).C-H Trifluoromethylation of 2-Substituted/Unsubstituted Aminonaphthoquinones at Room Temperature with Bench-Stable (CF3SO2)(2)Zn: Synthesis and Antiproliferative Evaluation.JOURNAL OF ORGANIC CHEMISTRY,82(13),6795-6800. |
| MLA | Li, Jing,et al."C-H Trifluoromethylation of 2-Substituted/Unsubstituted Aminonaphthoquinones at Room Temperature with Bench-Stable (CF3SO2)(2)Zn: Synthesis and Antiproliferative Evaluation".JOURNAL OF ORGANIC CHEMISTRY 82.13(2017):6795-6800. |
入库方式： OAI收割
来源：上海药物研究所
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