Synthesis and biological evaluation of new N-linked 5-triazolylmethyl oxazolidinones
文献类型：期刊论文
| 作者 | Fan, Houxing1; Chen, Yilang1; Jiang, Zhiteng1; Zhang, Shuhua2; Zhong, Dafang1 ; Ji, Ruyun1; Yang, Yushe1
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| 刊名 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2008-08 |
| 卷号 | 43期号:8页码:1706-1714 |
| 关键词 | oxazolidinone linezolid antibacterial agents gram-positive organisms |
| ISSN号 | 0223-5234 |
| DOI | 10.1016/j.ejmech.2007.09.010 |
| 文献子类 | Article |
| 英文摘要 | A new series of oxazolidinones bearing N-linked 5-triazolylmethyl group have been synthesized and their in vitro antibacterial activities (MIC) were evaluated against a spectrum of resistant and susceptible Gram-positive organisms. Some of the analogues in this series displayed activity superior to linezolid and vancomycin. Furthermore, in vivo efficacies and pharmacokinetic properties of the selected compounds were also disclosed herein; the selected compounds showed reasonable bioavailability as well as in vivo efficacy comparable to that of linezolid. (c) 2007 Elsevier Masson SAS. All rights reserved. |
| WOS关键词 | RESISTANT STAPHYLOCOCCUS-AUREUS ; ANTIBACTERIAL ACTIVITY ; COMMUNITY ; INFECTIONS ; RBX-7644 ; AGENTS |
| 资助项目 | National Natural Science Foundation of China[20672125] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000259161600015 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272850]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yang, Yushe |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Sichuan Ind Inst Antibiot, Chengdu 610051, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fan, Houxing,Chen, Yilang,Jiang, Zhiteng,et al. Synthesis and biological evaluation of new N-linked 5-triazolylmethyl oxazolidinones[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2008,43(8):1706-1714. |
| APA | Fan, Houxing.,Chen, Yilang.,Jiang, Zhiteng.,Zhang, Shuhua.,Zhong, Dafang.,...&Yang, Yushe.(2008).Synthesis and biological evaluation of new N-linked 5-triazolylmethyl oxazolidinones.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,43(8),1706-1714. |
| MLA | Fan, Houxing,et al."Synthesis and biological evaluation of new N-linked 5-triazolylmethyl oxazolidinones".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 43.8(2008):1706-1714. |
入库方式： OAI收割
来源：上海药物研究所
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