Structural modification of an angiogenesis inhibitor discovered from traditional Chinese medicine and a structure - Activity relationship study
文献类型：期刊论文
| 作者 | Yang, Sheng-Ping; Cai, Yu-Jun; Zhang, Bang-Le; Tong, Lin-Jiang; Xie, Hua ; Wu, Yan; Lin, Li-Ping; Ding, Jian; Yue, Jian-Min
|
| 刊名 | JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2008-01-10 |
| 卷号 | 51期号:1页码:77-85 |
| ISSN号 | 0022-2623 |
| DOI | 10.1021/jm070906g |
| 文献子类 | Article |
| 英文摘要 | Pseudolaric acid B (PAB), discovered as a promising angiogensis inhibitor, was served as the anticancer drug lead, and a series of its derivatives were synthesized. Among them, some derivatives, such as 13c-13k, exhibited potent inhibition on the HMEC-1 cell proliferation and strong cytotoxic activities against the tested six tumor cell lines. The PAB derivatives 13c-13k also showed significant and specific inhibition on HMEC-1 cell migration in vitro, and only 13d expressed moderate activity against HMEC-1 cell tube formation. The in vitro anticancer tests of the selected natural PAB analogs and the structurally modified PAB derivatives have led to the establishment of a clear structure-activity relationship. |
| WOS关键词 | PSEUDOLARIC-ACID-B ; KAEMPFERI ; DITERPENOIDS ; DEGRADATION ; STRATEGY ; CELLS |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000252127200008 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273005]  |
| 专题 | 药理学第一研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 天然药物化学研究室 |
| 通讯作者 | Ding, Jian |
| 作者单位 | Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Sheng-Ping,Cai, Yu-Jun,Zhang, Bang-Le,et al. Structural modification of an angiogenesis inhibitor discovered from traditional Chinese medicine and a structure - Activity relationship study[J]. JOURNAL OF MEDICINAL CHEMISTRY,2008,51(1):77-85. |
| APA | Yang, Sheng-Ping.,Cai, Yu-Jun.,Zhang, Bang-Le.,Tong, Lin-Jiang.,Xie, Hua.,...&Yue, Jian-Min.(2008).Structural modification of an angiogenesis inhibitor discovered from traditional Chinese medicine and a structure - Activity relationship study.JOURNAL OF MEDICINAL CHEMISTRY,51(1),77-85. |
| MLA | Yang, Sheng-Ping,et al."Structural modification of an angiogenesis inhibitor discovered from traditional Chinese medicine and a structure - Activity relationship study".JOURNAL OF MEDICINAL CHEMISTRY 51.1(2008):77-85. |
入库方式： OAI收割
来源：上海药物研究所
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