Aza analogues of equol: Novel ligands for estrogen receptor beta
文献类型：期刊论文
| 作者 | Chen, Wuhong; Lin, Zhaohu; Ning, Mengmeng ; Yang, Chunhao; Yan, Xueming; Xie, Yuyuan; Shen, Xu; Wang, Ming-Wei
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY
 |
| 出版日期 | 2007-09-01 |
| 卷号 | 15期号:17页码:5828-5836 |
| 关键词 | 3-phenyl-tetrahydroquinoline ER beta equol |
| ISSN号 | 0968-0896 |
| DOI | 10.1016/j.bmc.2007.05.071 |
| 文献子类 | Article |
| 英文摘要 | 3-Aryl-tetrahydroquinolines, aza analogues of equol, are synthesized and evaluated for their binding properties to the estrogen receptors ER alpha and ER beta. Several of these compounds exhibited binding selectivity for ER similar to that of genistein. Compounds 8c and 8d were found to have dual actions: antagonists for ERa and agonists for ER beta in a yeast two-hybrid assay. These compounds have no estrogenic effects on the uterus and bone in vivo. (c) 2007 Elsevier Ltd. All rights reserved. |
| WOS关键词 | STRUCTURE-BASED DESIGN ; ER-BETA ; SELECTIVE LIGANDS ; MOLECULAR-BASIS ; ALPHA ; TETRAHYDROFLUORENONES ; METABOLITE ; PROSTATE ; AGONISTS ; MICE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000248779000014 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273154]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Yang, Chunhao |
| 作者单位 | 1.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Natl Ctr Drug Screening, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Wuhong,Lin, Zhaohu,Ning, Mengmeng,et al. Aza analogues of equol: Novel ligands for estrogen receptor beta[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2007,15(17):5828-5836. |
| APA | Chen, Wuhong.,Lin, Zhaohu.,Ning, Mengmeng.,Yang, Chunhao.,Yan, Xueming.,...&Wang, Ming-Wei.(2007).Aza analogues of equol: Novel ligands for estrogen receptor beta.BIOORGANIC & MEDICINAL CHEMISTRY,15(17),5828-5836. |
| MLA | Chen, Wuhong,et al."Aza analogues of equol: Novel ligands for estrogen receptor beta".BIOORGANIC & MEDICINAL CHEMISTRY 15.17(2007):5828-5836. |
入库方式： OAI收割
来源：上海药物研究所
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