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Predictina protein-protein interactions based only on sequences information

文献类型：期刊论文

作者Shen, Juwen; Zhang, Jian; Luo, Xiaomin; Zhu, Weiliang; Yu, Kunqian; Chen, Kaixian; Li, Yixue; Jiang, Hualiang
刊名PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
出版日期2007-03-13
卷号104期号:11页码:4337-4341
关键词conjoint triad support vector machine
ISSN号0027-8424
DOI10.1073/pnas.0607879104
文献子类Article
英文摘要Protein-protein interactions (PPIs) are central to most biological processes. Although efforts have been devoted to the development of methodology for predicting PPIs and protein interaction networks, the application of most existing methods is limited because they need information about protein homology or the interaction marks of the protein partners. In the present work, we propose a method for PPI prediction using only the information of protein sequences. This method was developed based on a learning algorithm-support vector machine combined with a kernel function and a conjoint triad feature for describing amino acids. More than 16,000 diverse PPI pairs were used to construct the universal model. The prediction ability of our approach is better than that of other sequence-based PPI prediction methods because it is able to predict PPI networks. Different types of PPI networks have been effectively mapped with our method, suggesting that, even with only sequence information, this method could be applied to the exploration of networks for any newly discovered protein with unknown biological relativity. In addition, such supplementary experimental information can enhance the prediction ability of the method.
WOS关键词COMPLEX CELLULAR-SYSTEMS ; INTERACTION NETWORKS ; SIGNALING NETWORKS ; YEAST ; ORGANIZATION
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000244972700019
出版者NATL ACAD SCIENCES
源URL[http://119.78.100.183/handle/2S10ELR8/273306]  
专题药物发现与设计中心
中科院受体结构与功能重点实验室
新药研究国家重点实验室
通讯作者Jiang, Hualiang
作者单位1.Chinese Acad Sci, Ctr Drug Discovery & Design, State Key Lab Drug Res, Shanghai Inst Mat Med,Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Biol Sci, Bioinformat Ctr, Shanghai 200031, Peoples R China
3.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
4.Chinese Acad Sci, Grad Sch, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Shen, Juwen,Zhang, Jian,Luo, Xiaomin,et al. Predictina protein-protein interactions based only on sequences information[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2007,104(11):4337-4341.
APA Shen, Juwen.,Zhang, Jian.,Luo, Xiaomin.,Zhu, Weiliang.,Yu, Kunqian.,...&Jiang, Hualiang.(2007).Predictina protein-protein interactions based only on sequences information.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,104(11),4337-4341.
MLA Shen, Juwen,et al."Predictina protein-protein interactions based only on sequences information".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104.11(2007):4337-4341.

入库方式： OAI收割

来源：上海药物研究所

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