Isolation of acetylcholinesterase G4 and G1 molecular isoforms from rat cortex
文献类型：期刊论文
| 作者 | Zhao, Q ; Tang, XC
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2002-02 |
| 卷号 | 23期号:2页码:173-176 |
| 关键词 | acetylcholinesterase chromatography ultracentrifugation rats |
| ISSN号 | 1671-4083 |
| 文献子类 | Article |
| 英文摘要 | AIM: To isolate the G4 and G1 molecular forms of acetylcholinesterase in rat cortex for interpreting the therapeutical effect of the AChE inhibitor drugs. METHODS: Size exclusion chromatography, and ultracentrifugation were used to isolate and ascertain the G4 and G1 molecular forms of AChE. RESULTS: After size exclusion chromatography, two AChE active peaks were gotten. The putative molecular weights of the two highest AChE active fractions were around M-r 239 000 and M-r 68 000 respectively, which represented G4 and G1 AChE isoforms. The sedimentation coefficients of the M-r 239 000 and M, 68 000 fractions were 10 S and 4 S, which also assigned to G4 and G1 AChE isoforms. CONCLUSION: The G4 and G1 isoforms of AChE could be gotten by size exclusion chromatography method. |
| WOS关键词 | BRAIN ; FORMS ; ALZHEIMERS ; INHIBITION ; DISEASES |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:1366749 |
| WOS记录号 | WOS:000173710300015 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274391]  |
| 专题 | 院士及顾问专家 中科院受体结构与功能重点实验室 新药研究国家重点实验室 药物靶标结构与功能中心 |
| 通讯作者 | Tang, XC |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, State Key Lab Drug Res, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Q,Tang, XC. Isolation of acetylcholinesterase G4 and G1 molecular isoforms from rat cortex[J]. ACTA PHARMACOLOGICA SINICA,2002,23(2):173-176. |
| APA | Zhao, Q,&Tang, XC.(2002).Isolation of acetylcholinesterase G4 and G1 molecular isoforms from rat cortex.ACTA PHARMACOLOGICA SINICA,23(2),173-176. |
| MLA | Zhao, Q,et al."Isolation of acetylcholinesterase G4 and G1 molecular isoforms from rat cortex".ACTA PHARMACOLOGICA SINICA 23.2(2002):173-176. |
入库方式： OAI收割
来源：上海药物研究所
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