Design, synthesis and biological evaluation of biphenylurea derivatives as VEGFR-2 kinase inhibitors (II)
文献类型：期刊论文
| 作者 | Gao, Guo-Rui2; Li, Meng-Yuan1,3; Lv, Yong-Cong4; Cao, Su-Fen2; Tong, Lin-Jiang3; Wei, Li-Xin1; Ding, Jian3 ; Xie, Hua3; Duan, Wen-Hu2,4
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| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2016-02 |
| 卷号 | 27期号:2页码:200-204 |
| 关键词 | Angiogenesis Kinase Inhibitor VEGFR-2 |
| ISSN号 | 1001-8417 |
| DOI | 10.1016/j.cclet.2015.10.004 |
| 文献子类 | Article |
| 英文摘要 | Inhibition of VEGFR-2 signaling pathway is one of the most promising approaches for the treatment of cancer. In this paper, we reported the design, synthesis, and biological evaluation of a series of biphenylurea derivatives as VEGFR-2 inhibitors. Among these compounds, 39 exhibited potent inhibitory activity against VEGFR-2 both in vitro and in vivo. The antiangiogenesis activity of 39 was further confirmed by both tube formation assay and chick chorioallantoic membrane assay. (c) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved. |
| WOS关键词 | GROWTH-FACTOR RECEPTOR-2 ; POTENT ; ANGIOGENESIS ; DISCOVERY ; SORAFENIB ; TOXICITY ; CANCER |
| 资助项目 | National Natural Science Foundation of China[81273365] ; National Natural Science Foundation of China[81173080] ; National Natural Science Foundation of China[81321092] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2012ZX09103101-024] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2014ZX09304002-008-001] ; Chinese National Programs for High Technology Research and Development[2012AA020302] ; Shanghai Science and Technology Commission[12DZ1930802] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5667504 |
| WOS记录号 | WOS:000396297800004 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276170]  |
| 专题 | 药物化学研究室 中科院受体结构与功能重点实验室 新药研究国家重点实验室 |
| 通讯作者 | Duan, Wen-Hu |
| 作者单位 | 1.Chinese Acad Sci, Pharmacol & Safety Evaluat Key Lab Tibetan Med Qi, Northwest Inst Plateau Biol, Xining 810008, Peoples R China 2.East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Gao, Guo-Rui,Li, Meng-Yuan,Lv, Yong-Cong,et al. Design, synthesis and biological evaluation of biphenylurea derivatives as VEGFR-2 kinase inhibitors (II)[J]. CHINESE CHEMICAL LETTERS,2016,27(2):200-204. |
| APA | Gao, Guo-Rui.,Li, Meng-Yuan.,Lv, Yong-Cong.,Cao, Su-Fen.,Tong, Lin-Jiang.,...&Duan, Wen-Hu.(2016).Design, synthesis and biological evaluation of biphenylurea derivatives as VEGFR-2 kinase inhibitors (II).CHINESE CHEMICAL LETTERS,27(2),200-204. |
| MLA | Gao, Guo-Rui,et al."Design, synthesis and biological evaluation of biphenylurea derivatives as VEGFR-2 kinase inhibitors (II)".CHINESE CHEMICAL LETTERS 27.2(2016):200-204. |
入库方式： OAI收割
来源：上海药物研究所
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